# US 10,117,882 B2 · Anti-inflammatory properties of marine lipid compositions

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- Number: US 10,117,882 B2
- Document ID: US10117882B2
- Status: Granted
- Kind: B2
- Application number: 12/849,950
- Filed: 2010-08-04
- Published: 2010-12-16
- Granted: 2018-11-06
- Earliest claimed: 2006-05-05
- Assignees: Aker Biomarine Antarctic AS
- Applicants: Inge Bruheim; Mikko Griinari; Sebastiano Banni; Per Christian Saebo; Erik Fuglseth
- Inventors: Inge Bruheim; Mikko Griinari; Sebastiano Banni; Per Christian Saebo; Erik Fuglseth
- Web page: https://patentgrep.com/patent/US10117882B2

## CPC

- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07F 9/10: Phosphatides, e.g. lecithin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.

## Claims

### Claim 1

A gel capsule containing a lipid composition comprising a mixture of phospholipid molecules, having the following general structure:
wherein said mixture of phospholipid molecules is characterized in comprising at least 1% docosahexaenoic acid (DHA) residues or eicosopentaenoic acid (EPA) residues at positions R1 or R2 and from 15 to 45% of OH at positions R1 or R2 and wherein R1 and R2 are not simultaneously —OH, wherein R3 is a moiety selected from the group consisting of choline, ethanolamine, inositol and serine moieties, and wherein said mixture of phospholipids is acylated in a range from 55% to about 85%.

### Claim 2 (depends on 1)

The composition as claimed in claim 1, wherein said mixture of phospholipids has a ratio of EPA/DHA ranging from 1:1 to 4:1.

### Claim 3 (depends on 1)

The composition of claim 1, wherein said mixture of phospholipids having a ratio of EPA/DHA ranging from 2:1 to 4:1.

### Claim 4 (depends on 1)

The composition of claim 1, wherein said composition further comprises a lipid carrier in a ratio of from 1:10 to 10:1 to said phospholipids.

### Claim 5 (depends on 4)

The composition of claim 4, wherein said lipid carrier is selected from the group consisting of a triglyceride, a diglyceride, fatty acid ethyl ester, and a fatty acid methyl ester and combinations thereof.

### Claim 6 (depends on 4)

The composition of claim 4, wherein said lipid carrier and said mixture of phospholipids are in a ratio of from about 5:1 to 1:5.

### Claim 7 (depends on 4)

The composition of claim 4, wherein said composition comprises from about 20% to about 90% of said mixture of phospholipids and from about 10% to about 50% of said lipid carrier.