# US 10,117,865 B2 · CCR6 compounds

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- Number: US 10,117,865 B2
- Document ID: US10117865B2
- Status: Granted
- Kind: B2
- Application number: 15/709,012
- Filed: 2017-09-19
- Published: 2018-04-05
- Granted: 2018-11-06
- Earliest claimed: 2013-12-02
- Assignees: ChemoCentryx, Inc.
- Applicants: Chemocentryx, Inc.
- Inventors: Daniel Dairaghi; Dean R. Dragoli; Jaroslaw Kalisiak; Christopher W. Lange; Manmohan Reddy Leleti; Yandong Li; Rebecca M. Lui; Venkat Reddy Mali; Viengkham Malathong; Jay P. Powers; Hiroko Tanaka; Joanne Tan; Matthew J. Walters; Ju Yang; Penglie Zhang
- Web page: https://patentgrep.com/patent/US10117865B2

## CPC

- A61K 31/47: Quinolines; Isoquinolines
- A61K 31/4709: Non-condensed quinolines and containing further heterocyclic rings
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 5/16: for decreasing, blocking or antagonising the activity of the thyroid hormones
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 11/06: Antiasthmatics
- A61P 15/02: for disorders of the vagina
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/04: Antipruritics
- A61P 17/06: Antipsoriatics
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 215/48: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D 405/04: directly linked by a ring-member-to-ring-member bond
- C07D 405/14: containing three or more hetero rings
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:

## Claims

### Claim 1

A compound having the formula
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A compound of claim 1, having the formula

### Claim 3

A compound having the formula
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 3)

A compound of claim 3, having the formula

### Claim 5

A compound having the formula
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 5)

A compound of claim 5, having the formula