# US 10,117,863 B2 · Methods and compositions for enhancing female sexual arousal and treating female sexual dysfunction

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- Number: US 10,117,863 B2
- Document ID: US10117863B2
- Status: Granted
- Kind: B2
- Application number: 14/927,902
- Filed: 2015-10-30
- Published: 2017-05-04
- Granted: 2018-11-06
- Earliest claimed: 2010-04-15
- Assignees: Life Science Enhancement Corporation
- Applicants: Guy M. Stofman; Michael J. Pelekanos
- Inventors: Guy M. Stofman; Michael J. Pelekanos
- Web page: https://patentgrep.com/patent/US10117863B2

## CPC

- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Methods and compositions for enhancing female sexual arousal and treating female sexual dysfunction utilize L-arginine or equivalents and/or derivatives thereof, and an agent that enhances the activity of the L-arginine or equivalent thereof. These enhancing agents include niacin and/or nicotinamide. Niacin and/or nicotinamide, in combination with L-arginine or its equivalent allow a desired amount of nitric oxide to be delivered or generated at the female genitals in order to increase vasodilation and blood flow to the area to enhance sexual arousal and/or pleasure and to treat sexual dysfunction.

## Claims

### Claim 1

A composition comprising: an effective amount of L-arginine, an effective amount of niacin, an effective amount of nicotinamide, and an anti-oxidant comprising at least one of ascorbic ester C, dehydro-L-ascorbate, ester C of dehydro-L-ascorbate, ascorbic acid palmitate.

### Claim 2 (depends on 1)

The composition of claim 1 wherein the concentration of L-arginine is about 15% to about 45% w/w.

### Claim 3 (depends on 1)

The composition of claim 1 wherein the concentration of niacin is about 0.05% to 0.5% w/w.

### Claim 4 (depends on 1)

The composition of claim 1 wherein the concentration of nicotinamide is about 0.005% to 0.05% w/w.