# US 10,117,842 B2 · Methods and materials for reducing ischemia-reperfusion injury

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,117,842 B2
- Document ID: US10117842B2
- Status: Granted
- Kind: B2
- Application number: 15/503,642
- Filed: 2015-08-11
- Published: 2017-09-21
- Granted: 2018-11-06
- Earliest claimed: 2014-08-12
- Assignees: The University of Pécs (Pécsi Tudományegyetem)
- Applicants: The University of Pécs (Pécsi Tudományegyetem)
- Inventors: Agnes Nagy
- Web page: https://patentgrep.com/patent/US10117842B2

## CPC

- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 47/02: Inorganic compounds
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61B 17/12109: {in a blood vessel}
- A61B 17/122: Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

This document provides methods and materials for reducing ischemia-reperfusion injury. For example, methods and materials for administering ABA to reduce tissue injury caused by reperfusion following ischemia are provided.

## Claims

### Claim 1

A method for performing surgery within a mammal, wherein said method comprises:
(a) applying an occlusion to a blood vessel within said mammal to create ischemic tissue within said mammal,
(b) administering a composition comprising abscisic acid to said mammal, and
(c) removing said occlusion to restore blood flow to said ischemic tissue.

### Claim 2 (depends on 1)

The method of claim 1, wherein said mammal is a human.

### Claim 3 (depends on 1)

The method of claim 1, wherein said surgery is an embolectomy, a thrombectomy, a bypass surgery, an angioplasty, a carotid surgery, a coronary artery surgery, or an aortic surgery.

### Claim 4 (depends on 1)

The method of claim 1, wherein said occlusion is applied using a surgical clamp.

### Claim 5 (depends on 1)

The method of claim 1, wherein said blood vessel is an artery.

### Claim 6 (depends on 1)

The method of claim 1, wherein said ischemic tissue is brain tissue, myocardial tissue, or skeletal muscle tissue.