Sulfur(VI) fluoride compounds and methods for the preparation thereof
AssigneeThe Scripps Research Institute
InventorsJiajia Dong, K. Barry Sharpless, Jeffery W. Kelly, Wentao Chen
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AssigneeThe Scripps Research Institute
InventorsJiajia Dong, K. Barry Sharpless, Jeffery W. Kelly, Wentao Chen
Estimating the term…
This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.
An amino protected O-fluorosulfonyl-L-tyrosine of formula:
A polypeptide comprising an O-fluorosulfonyl-L-tyrosine residue.
Dependencies are inferred from the claim text.