# US 10,117,827 B2 · Preparations for suppressing or attenuating ocular irritancy

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- Number: US 10,117,827 B2
- Document ID: US10117827B2
- Status: Granted
- Kind: B2
- Application number: 15/102,402
- Filed: 2014-12-08
- Published: 2017-01-26
- Granted: 2018-11-06
- Earliest claimed: 2013-12-08
- Assignees: Y&B Mother's Choice Ltd.
- Applicants: Y&B Mother's Choice Ltd.
- Inventors: Rachel Lutz; Alexander Besonov; Tova Silberstein
- Web page: https://patentgrep.com/patent/US10117827B2

## CPC

- A61K 8/982: {Reproductive organs; Embryos, Eggs}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/553: {Phospholipids, e.g. lecithin}
- A61K 8/60: Sugars; Derivatives thereof
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/73: Polysaccharides
- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 8/92: Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K 8/922: {of vegetable origin}
- A61K 8/9706: Algae
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61P 27/02: Ophthalmic agents
- A61Q 5/02: Preparations for cleaning the hair
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/524: Preservatives
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K 2800/596: Mixtures of surface active compounds
- A61K 2800/75: Anti-irritant
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided is a tear-free formulation for suppressing or reducing ocular irritancy of a pre-made cosmetic or therapeutic formulation or an ophthalmic formulation suitable for application to an eye of a subject or to a skin region surrounding an eye of a subject.

## Claims

### Claim 1

A method for reducing, diminishing or ameliorating irritation to an eye region or to a skin region surrounding the eye, the method comprising topically administering to the eye region or to the skin region surrounding the eye a formulation selected from the group consisting of:
(i) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and sodium hyaluronate;
(ii) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan;
(iii) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and at least one polyol selected from mannitol, glycerol, zemea and trehalose; and
(iv) soy-bean lecithin, jojoba oil, squalene oil, egg yolk, at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan, and at least one polyol selected from mannitol, glycerol, zemea and trehalose.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the formulation is selected from the group consisting of (A) a baby shampoo, baby bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human infant skin; or from the group consisting of (B) adult shampoo, adult bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human adult skin.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the formulation further comprising at least one additional additive selected from the group consisting of phospholipids, polysaccharides, polyols, saponins, salicilates, preservatives, perfumes, natural coloring agents, emollients, non-aqueous or aqueous solvents or mixtures, and other active or non-active components.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the formulation further comprising at least one preservative.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the formulation further comprising at least one saponin.

### Claim 6 (depends on 1)

A method of reducing, diminishing or ameliorating irritation to an eye region or to a skin region surrounding the eye, said irritation being associated with at least one skin care formulation, the method comprising adding on to said skin care formulation a formulation according to claim 1 to obtain an add on formulation, wherein said skin care formulation is selected from the group consisting of (A) a baby shampoo, baby bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human infant skin; or from the group consisting of (B) adult shampoo, adult bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human adult skin.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the add on formulation comprises at least one saponin selected from the group consisting of Sapindus mukorossi extract, Camellia oleifera extract and Quillaja extract; Aspen bark extract; soy-bean lecithin; Jojoba oil; Squalene oil; Egg yolk; at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan; and at least one polyol selected from mannitol, glycerol, zemea and trehalose.

### Claim 8 (depends on 1)

A method for suppressing or reducing ocular irritancy of a pre-made cosmetic or therapeutic formulation or an ophthalmic formulation suitable for application to an eye of a subject or to a skin region surrounding an eye of a subject, the cosmetic or therapeutic formulation being capable of causing irritation to an ocular membrane or to the eye's cornea, the method comprising adding on to said pre-made cosmetic or therapeutic formulation or an ophthalmic formulation a formulation according to claim 1.

### Claim 9 (depends on 6)

The method of claim 6, wherein the add on formulation comprises Sapindus mukorossi extract, Camellia oleifera extract, Quillaja extract, Aspen bark extract, soy-bean lecithin, jojoba oil, squalene oil, egg yolk, at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan; and at least one polyol selected from mannitol, glycerol, zemea and trehalose.

### Claim 10 (depends on 6)

The method of claim 6, wherein the add on formulation comprises 0.5-6 wt % of Sapindus mukorossi extract; 0.1-6 wt % of Camellia oleifera extract; 0.1-6 wt % of Quillaja extract; 0.1-0.8 wt % of Aspen bark extract; 0.1-5 wt % of soy-bean lecithin; 0.2-4 wt % of jojoba oil; 0.2-4 wt % of squalene oil; 0.2-5 wt % of egg yolk; at least one polysaccharide selected from sodium hyaluronate up to 0.8 wt %, xanthan gum up to 2.5 wt % and carrageenan up to 2.5 wt %; at least one polyol selected from mannitol up to 2.5 wt % and glycerol up to 2.5 wt %, and optionally zemea up to 15 wt % and/or trehalose up to 2.5 wt %; and optionally perfume up to 1.5 wt %.