# US 10,117,614 B2 · Method and system for providing continuous calibration of implantable analyte sensors > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,117,614 B2 - Document ID: US10117614B2 - Status: Granted - Kind: B2 - Application number: 14/850,957 - Filed: 2015-09-11 - Published: 2016-01-07 - Granted: 2018-11-06 - Earliest claimed: 2006-02-08 - Assignees: Abbott Diabetes Care Inc. - Applicants: Abbott Diabetes Care Inc. - Inventors: Benjamin Jay Feldman - Web page: https://patentgrep.com/patent/US10117614B2 ## CPC - A61B 5/1495: Calibrating or testing of in-vivo probes - A61B 5/0017: {transmitting optical signals} - A61B 5/0024: {for multiple sensor units attached to the patient, e.g. using a body or personal area network} - A61B 5/0031: {Implanted circuitry} - A61B 5/14503: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence)} - A61B 5/6846: {specially adapted to be brought in contact with an internal body part, i.e. invasive} - A61B 5/7246: {using correlation, e.g. template matching or determination of similarity} - A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure} - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - H04L 67/12: specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA - H04L: TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION (arrangements common to telegraphic and telephonic communication H04M) ## Abstract Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed. ## Claims ### Claim 1 A method of analyte sensor calibration, comprising: receiving analyte signals from a first analyte sensor positioned in fluid contact with bodily fluid under a skin surface during a first time period; receiving analyte signals from a second analyte sensor positioned in fluid contact with bodily fluid under a skin surface during a second time period; defining an overlap time period beginning with the positioning of the second analyte sensor and ending with the removal of the first analyte sensor from fluid contact with the bodily fluid; determining that the second analyte sensor meets an acceptable stability level during the overlap time period; and transferring a calibration parameter associated with calibration of the first analyte sensor to calibration of the second analyte sensor, wherein the calibration parameter includes a scaling factor associated with the analyte signals from the first and second analyte sensors, and wherein the scaling factor is determined by performing an autocorrelation function. ### Claim 2 (depends on 1) The method of claim 1, wherein determining that the second analyte sensor meets the acceptable stability level includes correlating the signals generated by the second analyte sensor with the signals from the first analyte sensor during the overlap time period. ### Claim 3 (depends on 1) The method of claim 1, further including calibrating the second analyte sensor solely based on the transferred calibration parameter. ### Claim 4 (depends on 1) The method of claim 1, wherein the level of accuracy of the signals from the calibrated first analyte sensor is the same as the level of accuracy of the signals from the calibrated second analyte sensor. ### Claim 5 (depends on 1) The method of claim 1, further including calibrating the first analyte sensor with a reference measurement. ### Claim 6 (depends on 1) The method of claim 1, wherein the second analyte sensor is calibrated without any reference measurement during the entire life of the second analyte sensor when positioned in fluid contact with the bodily fluid. ### Claim 7 A system for analyte sensor calibration, comprising: a first analyte sensor for positioning in fluid contact with bodily fluid under a skin surface during a first time period; a second analyte sensor for positioning in fluid contact with bodily fluid under a skin surface during a second time period; and one or more processors configured to process signals generated by the first and second analyte sensors, the one or more processors further configured to: define an overlap time period beginning with the positioning of the second analyte sensor and ending with the removal of the first analyte sensor from fluid contact with the bodily fluid; determine that the second analyte sensor meets an acceptable stability level during the overlap time period; perform an autocorrelation function to determine a scaling factor associated with the signals generated by the first and second analyte sensors; and transfer a calibration parameter associated with calibration of the first analyte sensor to calibration of the second analyte sensor, wherein the calibration parameter includes the scaling factor. ### Claim 8 (depends on 7) The system of claim 7, wherein the one or more processors is configured to correlate the signals generated by the second analyte sensor with the signals from the first analyte sensor during the overlap time period to determine that the second analyte sensor meets the acceptable stability level. ### Claim 9 (depends on 7) The system of claim 7, wherein the one or more processors is configured to calibrate the second analyte sensor solely based on the transferred calibration parameter. ### Claim 10 (depends on 7) The system of claim 7, wherein the level of accuracy of the signals from the calibrated first analyte sensor is the same as the level of accuracy of the signals from the calibrated second analyte sensor. ### Claim 11 (depends on 7) The system of claim 7, wherein the one or more processors is configured to calibrate the first analyte sensor with a reference measurement. ### Claim 12 (depends on 7) The system of claim 7, wherein the second analyte sensor is calibrated without any reference measurement during the entire life of the second analyte sensor when positioned in fluid contact with the bodily fluid. ### Claim 13 A method of analyte sensor calibration, comprising: receiving analyte signals from a first analyte sensor positioned in fluid contact with bodily fluid under a skin surface during a first time period; receiving analyte signals from a second analyte sensor positioned in fluid contact with bodily fluid under a skin surface during a second time period; defining an overlap time period beginning with the positioning of the second analyte sensor and ending with the removal of the first analyte sensor from fluid contact with the bodily fluid; determining that the second analyte sensor meets an acceptable stability level during the overlap time period; and transferring a calibration parameter associated with calibration of the first analyte sensor to calibration of the second analyte sensor, wherein the calibration parameter includes a scaling factor associated with the analyte signals from the first and second analyte sensors, and wherein the scaling factor is determined based on an average error between the signals generated by the first and second analyte sensor. ### Claim 14 (depends on 13) The method of claim 13, wherein determining that the second analyte sensor meets the acceptable stability level includes correlating the signals generated by the second analyte sensor with the signals from the first analyte sensor during the overlap time period. ### Claim 15 (depends on 13) The method of claim 13, further including calibrating the second analyte sensor solely based on the transferred calibration parameter. ### Claim 16 (depends on 13) The method of claim 13, wherein the level of accuracy of the signals from the calibrated first analyte sensor is the same as the level of accuracy of the signals from the calibrated second analyte sensor. ### Claim 17 (depends on 13) The method of claim 13, further including calibrating the first analyte sensor with a reference measurement. ### Claim 18 (depends on 13) The method of claim 13, wherein the second analyte sensor is calibrated without any reference measurement during the entire life of the second analyte sensor when positioned in fluid contact with the bodily fluid. ### Claim 19 A system for analyte sensor calibration, comprising: a first analyte sensor for positioning in fluid contact with bodily fluid under a skin surface during a first time period; a second analyte sensor for positioning in fluid contact with bodily fluid under a skin surface during a second time period; and one or more processors configured to process signals generated by the first and second analyte sensors, the one or more processors further configured to: define an overlap time period beginning with the positioning of the second analyte sensor and ending with the removal of the first analyte sensor from fluid contact with the bodily fluid; determine that the second analyte sensor meets an acceptable stability level during the overlap time period; determine a scaling factor associated with the signals generated by the first and second analyte sensors based on an average error between the signals generated by the first and second analyte sensors; and transfer a calibration parameter associated with calibration of the first analyte sensor to calibration of the second analyte sensor, wherein the calibration parameter includes the scaling factor. ### Claim 20 (depends on 19) The system of claim 19, wherein the one or more processors is configured to correlate the signals generated by the second analyte sensor with the signals from the first analyte sensor during the overlap time period to determine that the second analyte sensor meets the acceptable stability level. ### Claim 21 (depends on 19) The system of claim 19, wherein the one or more processors is configured to perform an autocorrelation function to determine the scaling factor. ### Claim 22 (depends on 19) The system of claim 19, wherein the one or more processors is configured to calibrate the second analyte sensor solely based on the transferred calibration parameter. ### Claim 23 (depends on 19) The system of claim 19, wherein the level of accuracy of the signals from the calibrated first analyte sensor is the same as the level of accuracy of the signals from the calibrated second analyte sensor. ### Claim 24 (depends on 19) The system of claim 19, wherein the one or more processors is configured to calibrate the first analyte sensor with a reference measurement. ### Claim 25 (depends on 19) The system of claim 19, wherein the second analyte sensor is calibrated without any reference measurement during the entire life of the second analyte sensor when positioned in fluid contact with the bodily fluid.