# US 10,117,606 B2 · Method and apparatus for detecting false hypoglycemic conditions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,117,606 B2 - Document ID: US10117606B2 - Status: Granted - Kind: B2 - Application number: 14/730,077 - Filed: 2015-06-03 - Published: 2015-09-24 - Granted: 2018-11-06 - Earliest claimed: 2009-10-30 - Assignees: Abbott Diabetes Care Inc. - Applicants: Abbott Diabetes Care Inc. - Inventors: Benjamin Jay Feldman; Adam Heller; Namvar Kiaie - Web page: https://patentgrep.com/patent/US10117606B2 ## CPC - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) - A61B 5/1451: {for interstitial fluid} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors} - A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided. ## Claims ### Claim 1 A system, comprising: an analyte sensor positioned in fluid contact with interstitial fluid under a skin layer and configured to generate signals corresponding to a monitored analyte level in the interstitial fluid; sensor electronics electrically coupled to the analyte sensor and configured to generate analyte data based on the signals generated by the analyte sensor; and a data receiver configured to receive the generated analyte data from the sensor electronics, the data receiver configured to trigger a hold assertion function to temporarily prevent the assertion of a programmed notification after the programmed notification has initiated when a rate of change of the monitored analyte level determined from the generated analyte data exceeds a predetermined analyte threshold during a monitoring time period, and to assert the programmed notification when the rate of change of a monitored temperature exceeds a predetermined temperature threshold during the monitoring time period. ### Claim 2 (depends on 1) The system of claim 1, wherein the predetermined analyte threshold includes a decreasing rate of the analyte level of approximately 2 mg/dL/minute. ### Claim 3 (depends on 1) The system of claim 1, wherein the asserted programmed notification indicates a hypoglycemic condition. ### Claim 4 (depends on 1) The system of claim 1, wherein the data receiver is configured to assert the programmed notification when a direction of the analyte level rate of change and a direction of the monitored temperature rate of change are the same. ### Claim 5 (depends on 1) The system of claim 1, wherein the monitored analyte level includes one or more of glucose level or lactate level. ### Claim 6 (depends on 1) The system of claim 1, wherein the data receiver is configured to receive monitored temperature information to determine the rate of change of the monitored temperature. ### Claim 7 (depends on 1) The system of claim 1, wherein the predetermined temperature threshold includes a decreasing rate of a temperature level of approximately 2° C./15 minutes. ### Claim 8 (depends on 1) The system of claim 1, wherein the analyte sensor includes a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode. ### Claim 9 (depends on 8) The system of claim 8, wherein the analyte-responsive enzyme is chemically bonded to the polymer disposed on the working electrode. ### Claim 10 (depends on 8) The system of claim 8, wherein the working electrode comprises a mediator bonded to the polymer disposed on the working electrode. ### Claim 11 (depends on 10) The system of claim 10, wherein the mediator is crosslinked with the polymer disposed on the working electrode. ### Claim 12 (depends on 1) The system of claim 1, wherein the analyte sensor includes a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode. ### Claim 13 A system, comprising sensor electronics configured to receive signals from an analyte sensor in fluid contact with interstitial fluid, and to generate analyte data corresponding to a monitored analyte level in interstitial fluid; and a data receiver configured to receive the generated analyte data from the sensor electronics, the data receiver configured to temporarily prevent the assertion of a programmed notification after the programmed notification has initiated when a rate of change of the monitored analyte level determined from the generated analyte data exceeds a predetermined analyte threshold during a monitoring time period, but to assert the programmed notification when a rate of change of a monitored temperature exceeds a predetermined temperature threshold during the monitoring time period. ### Claim 14 (depends on 13) The system of claim 13, wherein the predetermined analyte threshold includes a decreasing rate of the analyte level of approximately 2 mg/dL/minute. ### Claim 15 (depends on 13) The system of claim 13, wherein the predetermined temperature threshold includes a decreasing rate of a temperature level of approximately 2° C./15 minutes. ### Claim 16 (depends on 13) The system of claim 13, wherein the data receiver is configured to assert the programmed notification when a direction of the analyte level rate of change and a direction of the temperature level rate of change are the same.