# US 10,117,585 B2 · Sensor and biological signal measuring system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,117,585 B2 - Document ID: US10117585B2 - Status: Granted - Kind: B2 - Application number: 14/852,587 - Filed: 2015-09-13 - Published: 2016-03-31 - Granted: 2018-11-06 - Earliest claimed: 2014-09-29 - Assignees: Nihon Kohden Corporation - Applicants: Nihon Kohden Corporation - Inventors: Naoki Kobayashi; Hideaki Hirabara; Katsuyuki Horie; Tsuyoshi Shimizu; Kota Saeki - Web page: https://patentgrep.com/patent/US10117585B2 ## CPC - A61B 5/02028: {Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction} - A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)} - A61B 5/02233: {Occluders specially adapted therefor (tourniquets A61B17/132)} - A61B 5/0261: {using optical means, e.g. infrared light} - A61B 5/6831: {Straps, bands or harnesses} - A61B 5/0053: {by applying pressure, e.g. compression, indentation, palpation, grasping, gauging} - A61B 5/02422: {within occluders} - A61B 5/6814: {Head} - A61B 5/6824: {Arm or wrist} - A61B 5/6828: {Leg} - A61B 2560/0462: Apparatus with built-in sensors - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A biological signal measuring system includes a sensor and a biological signal measuring apparatus configured to calculate a blood refill time of a living tissue of a subject. The sensor includes a pressure applying portion configured to apply pressure on the living tissue, a light emitter configured to emit light toward the living tissue, a light receiver configured to receive reflected light or transmitted light from the living tissue, a first light transmitting member made of a light transmitting material and having one side contacting the light emitter and the other side arranged to contact the subject, a second light transmitting member made of a light transmitting material and having one side contacting the light receiver and the other side arranged to contact the subject, and a light blocking member configured to block light between the light emitter and the light receiver. ## Claims ### Claim 1 A sensor configured to measure a blood refill time of a living tissue of a subject, the sensor comprising: a pressure applying portion configured to apply pressure on the living tissue of the subject; a light emitter configured to emit light toward the living tissue of the subject; a light receiver configured to receive reflected light or transmitted light from the living tissue of the subject; a first light transmitting member being a single-piece member made of a light transmitting material, the first light transmitting member having one end configured as a contact surface contacting the light emitter and another end forming a contact surface to contact the subject; a second light transmitting member being a single-piece member made of a light transmitting material, the second light transmitting member having one end configured as a contact surface contacting the light receiver and another end forming the contact surface to contact the subject; and a light blocking member configured to block light between the light emitter and the light receiver. ### Claim 2 (depends on 1) The sensor according to claim 1, wherein the pressure applying portion comprises a bag configured to apply pressure on the living tissue of the subject when the bag is inflated. ### Claim 3 (depends on 2) The sensor according to claim 2, wherein the sensor is configured as a cuff that is wrapped around the subject to be held onto the subject. ### Claim 4 (depends on 1) The sensor according to claim 1, wherein the pressure applying portion is configured such that a time period from a start of a reduction of the pressure to an end of an application of the pressure is shorter than two seconds. ### Claim 5 (depends on 1) The sensor according to claim 1, wherein the contact surface to contact the subject comprises an adhesive material. ### Claim 6 (depends on 5) The sensor according to claim 5, wherein the pressure applying portion comprises a bag configured to apply pressure on the living tissue of the subject, wherein the sensor further comprises an elastic film provided on a surface opposite to the contact surface to cover the bag, and wherein an elastic modulus of the elastic film is greater than an elastic modulus of the bag. ### Claim 7 (depends on 1) The sensor according to claim 1, wherein the light emitter is configured to emit light of two or more wavelengths. ### Claim 8 (depends on 1) The sensor according to claim 1, further comprising a holding member on which the pressure applying portion is provided, wherein the light blocking member comprises a thin-film sheet on which the light emitter and the light receiver are provided; wherein the holding member is configured to hold the thin-film sheet and the pressure applying portion onto the subject. ### Claim 9 A sheet structure comprising: a light emitter configured to emit light toward a living tissue of a subject; a light receiver configured to receive reflected light or transmitted light from the living tissue of the subject; a first light transmitting member being a single-piece member made of a light transmitting material, the first light transmitting member having one end configured as a contact surface contacting the light emitter and another end forming a contact surface to contact the subject; a second light transmitting member being a single-piece member made of a light transmitting material, the second light transmitting member having one end configured as a contact surface contacting the light receiver and another end forming the contact surface to contact the subject; and a thin-film sheet configured to block light between the light emitter and the light receiver, the light emitter and the light receiver being provided on the thin-film sheet. ### Claim 10 A biological signal measuring system comprising: a sensor; and a biological signal measuring apparatus configured to calculate a blood refill time of a subject, wherein the sensor comprises: a pressure applying portion configured to apply pressure on a living tissue of the subject; a light emitter configured to emit light toward the living tissue of the subject; a light receiver configured to receive reflected light or transmitted light from the living tissue of the subject; a first light transmitting member made of a light transmitting material, the first light transmitting member having one end configured as a contact surface contacting the light emitter and another end forming a contact surface to contact the subject; a second light transmitting member made of a light transmitting material, the second light transmitting member having one end configured as a contact surface contacting the light receiver and another end forming the contact surface to contact the subject; and a light blocking member configured to block light between the light emitter and the light receiver, wherein the biological signal measuring apparatus is configured to calculate the blood refill time based on an amount of light received by the sensor. ### Claim 11 A biological signal measuring system comprising: a sensor configured as a cuff that is wrapped around a subject to be held onto the subject and configured to acquire a pressure change inside the cuff; and a biological signal measuring apparatus configured to calculate a blood refill time of the subject and a blood pressure of the subject, wherein the sensor comprises: a pressure applying portion comprising a bag configured to apply pressure on a living tissue of the subject when the bag is inflated; a light emitter configured to emit light toward the living tissue of the subject; a light receiver configured to receive reflected light or transmitted light from the living tissue of the subject; a first light transmitting member made of a light transmitting material, the first light transmitting member having one end configured as a contact surface contacting the light emitter and another end forming a contact surface to contact the subject; a second light transmitting member made of a light transmitting material, the second light transmitting member having one end configured as a contact surface contacting the light receiver and another end forming the contact surface to contact the subject; and a light blocking member configured to block light between the light emitter and the light receiver, wherein biological signal measuring apparatus is configured to calculate the blood refill time of the subject based on an amount of light received by the sensor, and to calculate the blood pressure of the subject based on the pressure change inside the cuff acquired by the sensor. ### Claim 12 (depends on 11) The biological signal measuring system according to claim 11, wherein the biological signal measuring apparatus comprises an input section allowing a user to select one of a first mode, a second mode and a third mode, and is configured to calculate the blood refill time of the subject when the first mode is selected, to calculate the blood pressure of the subject when the second mode is selected, and to calculate the both of the blood refill time of the subject and the blood pressure of the subject when the third mode is selected. ### Claim 13 (depends on 11) The biological signal measuring system according to claim 11, wherein the biological signal measuring apparatus is configured to calculate the blood refill time of the subject at a timing that has been set. ### Claim 14 (depends on 11) The biological signal measuring system according to claim 11, wherein the biological signal measuring apparatus is configured to calculate the blood pressure of the subject at a timing that has been set. ### Claim 15 (depends on 11) The biological signal measuring system according to claim 11, wherein the biological signal measuring apparatus is configured to start acquiring data to be used for a calculation of the blood pressure of the subject after the sensor starts an application of pressure on the living tissue of the subject, to end the application of pressure on the living tissue of the subject after acquiring the data to be used for the calculation of the blood pressure is ended, and to start measuring the blood refill time of the subject by using a change of amount of received light after the application of pressure is ended. ### Claim 16 A sensor configured to measure a blood refill time of a living tissue of a subject, the sensor comprising: a pressure applying portion having a bag configured to apply pressure on the living tissue of the subject; a light emitter configured to emit light toward the living tissue of the subject; a light receiver configured to receive reflected light or transmitted light from the living tissue of the subject; a light blocking member arranged between the light emitter and the light receiver; a light transmitting material forming a contact surface to contact the subject; and an elastic film provided on a surface opposite to the contact surface to cover the bag, wherein the light emitter and the light receiver are attached to the living tissue of the subject via the light transmitting material, wherein the light blocking member has a second light transmission rate that is lower than a first light transmission rate of the light transmitting material, and wherein an elastic modulus of the elastic film is greater than an elastic modulus of the bag.