# US 10,117,576 B2 · System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,117,576 B2 - Document ID: US10117576B2 - Status: Granted - Kind: B2 - Application number: 14/906,069 - Filed: 2014-07-21 - Published: 2016-06-09 - Granted: 2018-11-06 - Earliest claimed: 2013-07-19 - Assignees: The General Hospital Corporation - Applicants: The General Hospital Corporation - Inventors: Johannes F. de Boer; Koenraad Vermeer - Web page: https://patentgrep.com/patent/US10117576B2 ## CPC - A61B 3/113: for determining or recording eye movement - A61B 3/0008: {provided with illuminating means (A61B3/117, A61B3/14 take precedence)} - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/102: {for optical coherence tomography [OCT]} - A61B 3/14: Arrangements specially adapted for eye photography - A61B 5/7264: {Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems} - A61B 3/12: for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence) - A61B 3/18: Arrangement of plural eye-testing or -examining apparatus - A61B 5/7207: {of noise induced by motion artifacts} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The human eye is constantly in motion. For many imaging applications in the eye, eye motion on the time scale of the image acquisition distorts the images. For imaging applications where the signal is very low, image distortion is so severe that imaging is impossible. According to an exemplary embodiment of the present disclosure, systems, methods and computer-accessible medium can be provided to determine eye motion in real time, and provide real time correction of the eye motion for secondary imaging methods to provide stable images and permit long integration times of single images to increase the signal to noise. ## Claims ### Claim 1 An apparatus for determining tracking a motion of at least one portion of an anatomical structure, comprising: at least one detector first arrangement which is configured to simultaneously detect a plurality of electromagnetic radiations which are provided from multiple points within the at least one portion, wherein the electromagnetic radiations are received in a confocal configuration; and at least one computer second arrangement which is configured to (i) obtain at least one reference first image of the at least one portion, and (ii) generate at least one second image of the at least one portion based on the detected electromagnetic radiations, wherein the at least one second image has a lower resolution than the at least one reference first image, wherein the at least one second image is a subsampled full-field image that is subsampled based on a subset of pixel locations of the first image, and wherein the at least one computer second arrangement is further configured to determine the motion based on a comparison of the first and second images. ### Claim 2 (depends on 1) The apparatus according to claim 1, wherein the anatomical structure is an eye, and wherein the at least one computer second arrangement determines the motion of the at least one portion of the eye. ### Claim 3 (depends on 1) The apparatus according to claim 1, wherein the at least one computer second arrangement is configured to generate a plurality of the at least one second images, and determine the motion based on the comparison between the first image and each of the plurality of the at least one second images. ### Claim 4 (depends on 1) The apparatus according to claim 1, wherein the at least one computer second arrangement includes at least one particular device which includes at least one of a field programmable gated array (FPGA) or a complex programmable logic device (CPLD), and wherein the determination of the motion is performed by the at least one particular device. ### Claim 5 (depends on 1) The apparatus according to claim 1, further comprising a digital micromirror device (DMD) which at least one of (i) forwards a particular electromagnetic radiation to the at least one portion or (ii) provides the electromagnetic radiations from the at least one portion. ### Claim 6 (depends on 1) The apparatus according to claim 1, further comprising at least one polarizer, wherein the at least one polarizer forwards a particular electromagnetic radiation to the at least one portion, wherein the plurality of electromagnetic radiations are associated with the particular electromagnetic radiation. ### Claim 7 (depends on 6) The apparatus according to claim 6, wherein the particular electromagnetic radiation is provided via a digital micromirror device. ### Claim 8 (depends on 1) The apparatus of claim 1, further comprising a digital micromirror device (DMD), wherein the at least one detector first arrangement comprises a camera, and wherein the DMD forwards a particular electromagnetic radiation to the at least one portion and provides the plurality of electromagnetic radiations from the multiple points within the at least one portion to the camera. ### Claim 9 (depends on 8) The apparatus of claim 8, wherein the at least one second image is formed by activating a first plurality of mirror elements of the array of the DMD and inactivating a second plurality of mirror elements of the array of the DMD, different from the first plurality of mirror elements, and wherein the subset of pixel locations for the at least one second image corresponds to the first plurality of mirror elements. ### Claim 10 (depends on 1) The apparatus according to claim 1, further comprising at least one optical third arrangement which is controlled by the at least one computer second arrangement to adjust at least one component of at least one of optical component of mechanical components thereof based on the motion. ### Claim 11 (depends on 10) The apparatus according to claim 10, wherein the at least one component is adjusted to provide at least one further signal, and further comprising at least one computer fourth arrangement which is configured to generate a stabilized image of at least one of (i) the at least one portion or (ii) at least one further portion of the anatomical structure based on the at least one further signal. ### Claim 12 (depends on 11) The apparatus according to claim 11, wherein the fourth arrangement is part of an optical coherence tomography system. ### Claim 13 (depends on 10) The apparatus according to claim 10, wherein the at least one component is adjusted to provide a therapy to the at least one portion which is unaffected by the motion. ### Claim 14 (depends on 10) The apparatus according to claim 10, wherein the at least one component is adjusted to provide at least one further signal to the at least one computer second arrangement, and wherein the second arrangement is further configured to generate a stabilized image of at least one of (i) the at least one portion, or (ii) at least one further portion of the anatomical structure based on the at least one further signal. ### Claim 15 (depends on 14) The apparatus according to claim 14, wherein the at least one computer second arrangement is further configured to cause a generation of a further reference image based on the stabilized image, and determine the motion based on the comparison between the further reference image and the second image. ### Claim 16 A method for determining tracking a motion of at least one portion of an anatomical structure, comprising: simultaneously detecting a plurality of electromagnetic radiations which are provided from multiple points within the at least one portion, wherein the electromagnetic radiations are received in a confocal configuration; and obtaining at least one reference first image of the at least one portion; generating at least one second image of the at least one portion based on the detected electromagnetic radiations, wherein the at least one second image has a lower resolution than the at least one reference first image, and wherein the at least one second image is a subsampled full-field image that is subsampled based on a subset of pixel locations of the first image; and using a computer hardware arrangement, determining the motion based on a comparison of the first and second images. ### Claim 17 (depends on 16) The method according to claim 16, wherein the anatomical structure is an eye, and further comprising determining the motion of the at least one portion of the eye. ### Claim 18 (depends on 16) The method according to claim 16, further comprising generating a plurality of the at least one second images, and wherein the computer hardware arrangement is further configured to determine the motion based on the comparison between the first image and each of the plurality of the at least one second images. ### Claim 19 (depends on 16) The method according to claim 16, further comprising: (i) forwarding a particular electromagnetic radiation to the at least one portion using a digital micromirror device (DMD), (ii) forwarding the particular electromagnetic radiation from a polarizer to the at least one portion, wherein the plurality of electromagnetic radiations are associated with the particular electromagnetic radiation, or (iii) providing the electromagnetic radiations from the at least one portion using the DMD. ### Claim 20 (depends on 16) The method of claim 16, wherein simultaneously detecting the plurality of electromagnetic radiations further comprises: simultaneously detecting, using a camera, the plurality of electromagnetic radiations, and wherein the method further comprises: forwarding, using a digital micromirror device (DMD), a particular electromagnetic radiation to the at least one portion, and providing, using the DMD, the plurality of electromagnetic radiations from the multiple points within the at least one portion to the camera. ### Claim 21 (depends on 20) The method of claim 20, wherein generating the at least one second image further comprises: generating the at least one second image by activating a first plurality of mirror elements of the array of the DMD and inactivating a second plurality of mirror elements of the array of the DMD, different from the first plurality of mirror elements, and wherein the subset of pixel locations for the at least one second image corresponds to the first plurality of mirror elements. ### Claim 22 (depends on 16) The method according to claim 16, further comprising adjusting at least one component of at least one of optical component of mechanical components thereof based on the motion. ### Claim 23 (depends on 22) The method according to claim 22, further comprising: adjusting the at least one component to provide at least one further signal, and generating a stabilized image of at least one of (i) the at least one portion, or (ii) at least one further portion of the anatomical structure based on the at least one further signal. ### Claim 24 (depends on 23) The method according to claim 23, further comprising: causing a generation of a further reference image based on the stabilized image, and determining the motion based on the comparison between the further reference image and the at least one second image.