# US 10,117,563 B2 · Polyp detection from an image > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,117,563 B2 - Document ID: US10117563B2 - Status: Granted - Kind: B2 - Application number: 14/580,260 - Filed: 2014-12-23 - Published: 2015-07-09 - Granted: 2018-11-06 - Earliest claimed: 2014-01-09 - Assignees: Gyrus ACMI, Inc. - Applicants: Gyrus Acmi, Inc. - Inventors: Doron Adler - Web page: https://patentgrep.com/patent/US10117563B2 ## CPC - A61B 1/00009: {of image signals during a use of endoscope} - A61B 1/0005: {combining images e.g. side-by-side, superimposed or tiled} - A61B 1/0605: {for spatially modulated illumination} - A61B 1/0625: {for multiple fixed illumination angles} - A61B 1/0655: {Control therefor} - A61B 1/0676: {at distal tip of an endoscope} - C12N 15/101: {by chromatography, e.g. electrophoresis, ion-exchange, reverse phase} - C12Q 1/6806: Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay (C12Q1/6804 takes precedence) - G01N 27/44791: {Microapparatus (sample containers with integrated microfluidic structures B01L3/5027)} - G06T 7/0016: {involving temporal comparison} - G06T 7/254: involving subtraction of images - A61B 1/05: characterised by the image sensor, e.g. camera, being in the distal end portion - G06T 2207/10068: Endoscopic image - G06T 2207/30032: Colon polyp - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) - C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL ## Abstract A method of identifying the presence of a suspect region such as a polyp in a body cavity of a subject includes generating successive images of a body cavity of the subject, and comparing the successive images of the body cavity, wherein a suspect region of the body cavity is likely present when the successive images are different in terms of intensity, surroundings, registration, and/or protrusions. Also provided is an apparatus comprising a processor and an endoscope having a camera and one or more illuminators such that the processor is configured to compare the images acquired from the camera and the one or more illuminators to identify the presence of a suspect region such as a polyp. ## Claims ### Claim 1 A method for inspecting a body cavity, comprising: inserting an endoscope into the body cavity, the endoscope comprising a camera and a first illuminator and a second illuminator, similar to the first illuminator, in different, respective locations on the endoscope; acquiring with the camera a first image of the body cavity while the cavity is illuminated by the first illuminator and a second image of the cavity while the cavity is illuminated by the second illuminator; forming a comparison, by a processor, between the first image and the second image by calculating intensity differences between corresponding pixels of the first image and the second image; identifying, by the processor, an area of the body cavity as a suspect region in response to a difference in shadowing between the first and second images that is found in the comparison, by finding in the region a certain number of contiguous pixels for which the intensity differences are greater than an average intensity difference; and displaying one of the acquired images on a monitor while marking the suspect region on the one of the acquired images. ### Claim 2 (depends on 1) The method of claim 1, wherein the processor is integrated with the endoscope. ### Claim 3 (depends on 1) The method of claim 1, wherein the processor is separate from the endoscope. ### Claim 4 (depends on 1) The method of claim 1, wherein the processor is configured to form the comparison by calculating color, hue, saturation, and/or brightness differences between the corresponding pixels of the first image and the second image. ### Claim 5 (depends on 1) The method of claim 1, wherein the processor is configured to form the comparison through a registration step for both the first image and the second image. ### Claim 6 (depends on 1) The method of claim 1, wherein the suspect region comprises a polyp. ### Claim 7 An apparatus for inspecting a body cavity, the apparatus comprising: an endoscope configured to be inserted into the body cavity and comprising a camera and a first illuminator and a second illuminator, similar to the first illuminator, in different, respective locations on the endoscope, wherein the camera is configured to acquire a first image of the body cavity while the cavity is illuminated by the first illuminator and to acquire a second image of the cavity while the cavity is illuminated by the second illuminator; and a processor configured to form a comparison between the second image and the first image by calculating intensity differences between corresponding pixels of the first image and the second image, and to identify an area of the body cavity as a suspect region in response to a difference in shadowing between the first and second images that is found in the comparison, by finding in the region a certain number of contiguous pixels for which the intensity differences are greater than an average intensity difference, and to display one of the acquired images on a monitor while marking the suspect region on the one of the acquired images. ### Claim 8 (depends on 7) The apparatus of claim 7, wherein the suspect region comprises a polyp.