Method of producing microglial cells
AssigneeKyushu University, National University Corporation
InventorsTakahiro A. Kato, Masahiro Ohgidani, Shigenobu Kanba
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Abstract
The present invention provides a method of inducing microglia cells from blood cells, comprising culturing the blood cells in the presence of interleukin-34 (IL-34) and granulocyte-macrophage colony stimulating factor (GM-CSF).
Claims7
A method of producing microglial cells, comprising culturing blood cells in the presence of interleukin-34 (IL-34) and granulocyte-macrophage colony stimulating factor (GM-CSF), and collecting microglial cells from the culture.
A method of evaluating a responsiveness to a therapeutic drug and/or of screening a therapeutic drug for a psychiatric disease or a neurodegenerative disease, comprising the steps of:
- producing microglial cells by culturing blood cells in the presence of interleukin-34 (IL-34) and granulocyte-macrophage colony stimulating factor (GM-CSF), and collecting microglial cells from the culture;
- and
- causing the microglial cells produced to make contact with a candidate substance to measure a cellular activity of the cells produced;
- and
- using the obtained measurement result as an indicator.
Dependencies are inferred from the claim text.