BMP peptides and methods of use
AssigneeLifeNet Health
InventorsXiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
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Abstract
The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
Claims19
A peptide consisting of an amino acid sequence selected from SEQ ID NOs:
- 20, 21, 22, 24, 25, 26, 27 and 28.
A method of increasing a biological activity of a cell, comprising treating the cell with an effective amount of a peptide consisting of an amino acid sequence selected from SEQ ID NOs:
- 20-28, wherein the biological activity is selected from the group consisting of osteoinductive activity, chondroinductive activity, ligament/tendon differentiating activity, osteogenic activity and growth factor activity.
Dependencies are inferred from the claim text.