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US 10,106,490 B2Granted
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
AssigneeAcuitas Therapeutics, Inc.
InventorXinyao Du
Life of this patent
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Abstract
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
Claims19
A compound having the following structure:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is OH or Cl;
- each R is independently a saturated or unsaturated C1-C24 alkyl or saturated or unsaturated cycloalkyl;
- m is 0 or 1;
- and
- each n is independently an integer from 5 to 24.
3 more elements
Dependencies are inferred from the claim text.