Sustained-release drug carrier composition
AssigneePolypid Ltd.
InventorNoam Emanuel
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
Claims14
A method of treating osteomyelitis comprising the step of administering at or near the site of osteomyelitis a substrate having its surface at least partially coated with a matrix composition for sustained antibiotic release, the matrix composition comprising:
- a) a biodegradable polymer;
- b) a first lipid comprising a sterol;
- c) a second lipid comprising at least one phospholipid having fatty acid moieties of at least 14 carbons, and d) an antibiotic agent;
- wherein the matrix composition is lipid saturated, comprises at least 50% (w/w) lipids and has an ordered multilayer structure in which (i) the biodegradable polymer and lipid are ordered in the form of layers and (ii) when maintained in an aqueous environment the matrix composition provides sustained release of the antibiotic agent.
Dependencies are inferred from the claim text.