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US 10,105,191 B2Granted
Marking tissue surfaces for treatment of lesions by electrical nanopulses
AssigneePulse Biosciences, Inc.
InventorsCesar Escobar Blanco, Elena Tovkan Forster, Stefani Reiko Takahashi
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Abstract
This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.
Claims24
A system comprising:
- a pulse delivery device comprising at least one delivery electrode;
- and
- a decal configured for assisting in positioning the pulse delivery device on a surface of an object, the decal comprising:
- a film that is transferable to a region on the surface of the object;
- and
- a device guiding mark on the film that is transferable to the object surface together with the film and that is usable to position the pulse delivery device in relation to the object surface;
- wherein the film and the device guiding mark are configured to detachably attach to the object surface after the film is transferred to the object surface,
- wherein the pulse delivery device is configured to deliver at least one electrical pulse to the region after the film is transferred to the object surface;
- and
- wherein a distal end of the at least one delivery electrode is configured to pass through the film at the device guiding mark to be in contact with the region on the object surface.
7 more elements
A system comprising:
- a pulse delivery device comprising an applicator tip and at least one delivery electrode;
- and
- a decal configured for assisting in positioning the pulse delivery device on a surface of an object, the decal comprising:
- a film that is transferable to a region on the surface of the object, the region having a size corresponding to a treatment zone;
- a marked area on the film configured to indicate a boundary around the region after the film is transferred to the object surface;
- and
- at least one device guiding mark on the film that is transferable to the object surface together with the film and that is usable to position the pulse delivery device in relation to the object surface,
- wherein the film, the marked area and the at least one device guiding mark are configured to detachably attach to the object surface after the film is transferred to the object surface,
- wherein the pulse delivery device is configured to deliver at least one electrical pulse to the region after the film is transferred to the object surface;
- and
- wherein the at least one device guiding mark and the marked area indicating the boundary around the treatment zone are configured such that, after the at least one device guiding mark and the marked area are transferred to the object surface, when the applicator tip is aligned with the at least one device guiding mark, a distal end of the at least one delivery electrode is positioned inside an area defined by the marked area when brought in contact with the region on the object surface.
8 more elements
A system comprising:
- a pulse delivery device comprising an applicator tip having at least one delivery electrode and at least one device alignment line;
- and
- a decal configured for assisting in positioning the pulse delivery device on a surface of an object, the decal comprising:
- a film that is transferable to a region on the surface of the object;
- at least one device guideline on the film that is transferable to the object surface together with the film and that is usable to position the pulse delivery device in relation to the object surface, the film and the device guiding mark are configured to detachably attach to the object surface after the film is transferred to the object surface,
- wherein the pulse delivery device is configured to deliver at least one electrical pulse to the region after the film is transferred to the object surface;
- and
- wherein the at least one device alignment line of the applicator tip is usable with the device guideline of the film to orient the applicator tip and position a distal end of the at least one delivery electrode in relation to the region before delivery of at least one electrical pulse.
5 more elements
Dependencies are inferred from the claim text.