# US 10,104,894 B2 · Self-regenerating antimicrobial composition and method of use

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- Number: US 10,104,894 B2
- Document ID: US10104894B2
- Status: Granted
- Kind: B2
- Application number: 15/129,668
- Filed: 2015-03-18
- Published: 2017-06-22
- Granted: 2018-10-23
- Earliest claimed: 2014-03-31
- Assignees: Kimberly-Clark Worldwide, Inc.
- Applicants: Kimberly-Clark Worldwide, Inc.
- Inventors: David W. Koenig; Douglas R. Hoffman; Cindy Korir-Morrison; Amy L. Vanden Heuvel
- Web page: https://patentgrep.com/patent/US10104894B2

## CPC

- A01N 63/40: Viruses, e.g. bacteriophages
- A01N 25/10: Macromolecular compounds
- A01N 25/34: Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
- C09D 5/14: Paints containing biocides, e.g. fungicides, insecticides or pesticides (C09D5/16 takes precedence)
- C09D 7/65: macromolecular (C09D7/41-C09D7/48 take precedence)
- C12N 7/00: Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00)
- C08K 5/0058: {Biocides; (macromolecular substances as carriers for biocide material A01N25/10)}
- C12N 2750/00031: Uses of virus other than therapeutic or vaccine, e.g. disinfectant
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C08K: Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, adhesives C09)

## Abstract

A composition may be applied to animate and inanimate surfaces to render such surfaces antimicrobial for as long as the composition remains on the surface. The composition contains at least one pathogen-associated virus that is self-regenerating so that a user need not take steps to regenerate the material. The virus is or viruses are contained within a polymer matrix. The polymer matrix has the ability to maintain a desired moisture content to support the regeneration of the virus(es). Various methods of using the composition include the coating of animate and inanimate surfaces to prevent bacterial, viral, and fungal infections.

## Claims

### Claim 1

A composition for protecting a surface from pathogenic organisms, the composition comprising:
a hydrophilic polymer matrix; and
a pathogen-associated virus that replicates upon exposure to pathogenic organisms, the pathogen-associated virus being disposed within the polymer matrix;
wherein the polymer matrix allows the virus to replicate to support antimicrobial activity after the composition dries and upon being exposed to pathogenic organisms, and wherein the polymer matrix is a flexible absorbent binder comprising a monoethylenically unsaturated polymer and an acrylate or methacrylate ester including an alkoxysilane functionality.

### Claim 2 (depends on 1)

The composition of claim 1 wherein the pathogenic organisms are fungal.

### Claim 3 (depends on 1)

The composition of claim 1 wherein the pathogenic organisms are bacterial.

### Claim 4 (depends on 1)

The composition of claim 1 wherein the polymer matrix can maintain a Water of Activity of greater than 0.65 for 5 to 40 minutes of exposure to pathogenic organisms as measured by use of a Rototronic AG Water Activity and Temperature Probe.

### Claim 5 (depends on 1)

The composition of claim 1 wherein the virus is a bacteriophage.

### Claim 6 (depends on 1)

The composition of claim 1 wherein the virus is a mycophage.

### Claim 7 (depends on 1)

The composition of claim 1 wherein the virus is selected from the group consisting of an arthropod virus, an amoeba virus, and a protozoan virus.

### Claim 8

An antimicrobial wipe or wiper comprising:
an antimicrobial composition comprising a hydrophilic polymer matrix; and
a pathogen-associated virus that replicates upon exposure to pathogenic organisms, the pathogen-associated virus being disposed within the polymer matrix; wherein the polymer matrix allows the virus to replicate to support antimicrobial activity after the composition dries, and wherein the polymer matrix is selected from the group consisting of: flexible absorbent binder comprising a monoethylenically unsaturated polymer and an acrylate or methacrylate ester including an alkoxysilane functionality, cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly-(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethylether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid); polyethylene oxide, polyquaternium-16, polyquaternium-22; and mixtures thereof; and a basesheet; wherein the basesheet is saturated with the antimicrobial composition.

### Claim 9 (depends on 8)

The antimicrobial wipe or wiper of claim 8, wherein the base sheet comprises thermoplastic fibers and cellulose fibers.

### Claim 10 (depends on 8)

The antimicrobial wipe or wiper of claim 8 wherein the basesheet comprises a non-woven material.

### Claim 11 (depends on 8)

The antimicrobial wipe or wiper of claim 8 wherein the virus comprises a bacteriophage and/or a mycophage.

### Claim 12

A composition for protecting a surface from pathogenic organisms, the composition comprising:
a hydrophilic polymer matrix; and a pathogen-associated virus that replicates upon exposure to pathogenic organisms, the pathogen-associated virus being disposed within the polymer matrix; wherein the polymer matrix allows the virus to replicate to support antimicrobial activity after the composition dries and upon being exposed to pathogenic organisms, and wherein the polymer matrix is selected from the group consisting of cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly-(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid), polyethylene oxide, polyquaternium-16, polyquaternium-22, and mixtures thereof.

### Claim 13 (depends on 12)

The composition of claim 12, wherein the polymer matrix is configured to maintain a Water of Activity of greater than 0.65 for 5 to 40 minutes of exposure to pathogenic organisms as measured by use of a Rototronic AG Water Activity and Temperature Probe.