Monoclonal anti-TK1 antibodies

A monoclonal antibody or a fragment of a monoclonal antibody capable of binding to a serum form of human thymidine kinase 1, TK1, wherein said monoclonal antibody or fragment

• (a) has specificity for an epitope GEAVAARKLF (SEQ ID NO:
• 2) of said human TK1, and has:
• a variable heavy, VH, domain complementarity determining region 1, CDR1 having amino acid sequence (SEQ ID NO:
• 6);
• a VH domain CDR2 having amino acid sequence (SEQ ID NO:
• 7);
• a VH domain CDR3 having amino acid sequence (SEQ ID NO:
• 8);
• a variable light, VL, domain CDR1 having amino acid sequence (SEQ ID NO:
• 9);
• a VL domain CDR2 having amino acid sequence (SEQ ID NO:
• 10);
• and
• a VL domain CDR3 having amino acid sequence (SEQ ID NO:
• 11);
• (b) has specificity for a conformation dependent epitope of said human TK1, and has:
• a VH domain CDR1 having amino acid sequence (SEQ ID NO:
• 6);
• a VH domain CDR2 having amino acid sequence (SEQ ID NO:
• 12);
• a VH domain CDR3 having amino acid sequence (SEQ ID NO:
• 13);
• a VL domain CDR1 having amino acid sequence (SEQ ID NO:
• 14);
• a VL domain CDR2 having amino acid sequence (SEQ ID NO:
• 10);
• and
• a VL domain CDR3 having amino acid sequence (SEQ ID NO:
• 11);
• or
• (c) has specificity for at least one epitope selected from a group consisting of NCPVPGKPGE (SEQ ID NO:
• 4), PVPGKPGEAV (SEQ ID NO:
• 5) and NCPVPGKPGEAV (SEQ ID NO:
• 3) of said human TK1, and has:
• a VH domain CDR1 having amino acid sequence (SEQ ID NO:
• 15);
• a VH domain CDR2 having amino acid sequence (SEQ ID NO:
• 16);
• a VH domain CDR3 having amino acid sequence (SEQ ID NO:
• 17);
• a VL domain CDR1 having amino acid sequence (SEQ ID NO:
• 18);
• a VL domain CDR2 having amino acid sequence (SEQ ID NO:
• 19);
• and
• a VL domain CDR3 having amino acid sequence (SEQ ID NO:
• 20).