SHIP1 modulators and methods related thereto

A compound of formula (I):

• wherein:
• C1, C4, C11 and C12 are each independently substituted with two hydrogens;
• C9 is substituted with one hydrogen;
• C14 is substituted with one hydrogen when R5 is not a direct bond to C14;
• C15 is substituted with two hydrogens when R7 is not a direct bond to C15, and one hydrogen when R7 is a direct bond to C15;
• R1 is —R8—OR9 or —R8—N(R9)2;
• R2 is —R8—OR9, —R8—CN, —R8—C(O)OR9, —R8—C(O)N(R9)2, —R8—N(R9)2, —R8—N(R9)C(O)R9, optionally substituted heterocyclylalkyl or optionally substituted heteroarylalkyl;
• R4a and R4b together form methylene;
• R3 is —CH2—N(H)CH2-(2,2-difluorobenzodioxolyl), —CH2—CH2—N(4-methoxybenzyl)2, —CH2—CH2—N(H)-(4-methoxy)benzyl, —CH2—N(H)-(2-fluoro-4-methoxy)benzyl, —CH2—N(H)-(2-fluoro-4-methyl)benzyl, —CH2—N(H)-(2-methoxy-4-fluoro)benzyl, —CH2—N(H)-(2-methyl-4-fluoro)benzyl, —CH2—N(H)-(3,5-dimethoxy)benzyl, —CH2—N(H)-(4-fluoro)benzyl, —CH2—N(H)-(4-methoxy)benzyl, —CH2—N(H)-(4-trifluoromethyl)benzyl, —CH2—N(H)-(4-benzoyl)benzyl, —CH2—N(H)CH2-benzimidazolyl, —CH2—CH2—N(H)CH2-benzodioxolyl or —CH2—N(H)CH2CH2-(4-methoxy)phenyl;
• R5 is alkyl or R5 is a direct bond to C14;
• R6 is hydrogen;
• R7 is hydrogen, —R8—OR9 or a direct bond to C15;
• each R8 is independently a direct bond or a straight or branched alkylene chain;
• and
• each R9 is independently hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
• or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof;
• or a pharmaceutically acceptable salt or solvate thereof.