Computational systems for biomedical data

A system comprising:

• at least one electronic device including at least:
• circuitry for accepting at least one treatment target pertaining to at least one patient;
• circuitry for determining, based at least partly on a least one tissue sample from the at least one patient, at least one characteristic of a subpopulation, wherein the at least one characteristic includes at least one of a genetic expression parameter, an epigenetic expression parameter, or a demographic parameter;
• circuitry for receiving at least one input indicating at least one minimum level of efficacy for at least one treatment agent;
• circuitry for identifying at least one defined level of incidence of at least one adverse event, the defined level of incidence associated with the at least one characteristic of a subpopulation identifier;
• circuitry for identifying at least one treatment agent and at least one supplemental agent for use in the context of the at least one treatment target and the at least one defined level of incidence, including at least:
• circuitry for applying the at least one defined level of incidence and the at least one characteristic of the subpopulation identifier to identify at least one particular clinically relevant study data;
• circuitry for identifying a list of treatment agent options based at least partly on the defined level of incidence associated with the at least one characteristic of the subpopulation identifier, the at least one level of efficacy, and the identified at least one particular study data;
• and
• circuitry for identifying a corresponding list of supplemental agent options known to at least one of increase the efficacy or decrease the level of incidence of the at least one treatment agent;
• circuitry for transmitting for display on at least one display device the list of treatment options and the corresponding list of supplemental agent options, the options ranked based at least partly on the level of efficacy and the level of incidence when the at least one treatment agent is administered in conjunction with the at least one supplemental agent and correlating the treatment agent options with corresponding supplemental agent options;
• and
• circuitry for initiating administration of at least a portion of the at least one treatment agent and the at least one supplemental agent to the at least one patient.

A system comprising:

• a computing device;
• and
• instructions that when executed on the computing device cause the computing device to perform operations including at least:
• accept at least one treatment target pertaining to at least one patient via at least one user interface;
• determine, based at least partly on a least one tissue sample from the at least one patient, at least one characteristic of a subpopulation identifier, wherein the at least one characteristic includes at least one of a genetic expression parameter, an epigenetic expression parameter, or a demographic parameter;
• receive at least one input indicating at least one minimum level of efficacy for at least one treatment agent;
• identify at least one defined level of incidence of at least one adverse event, the defined level of incidence associated with the at least one characteristic of a subpopulation identifier;
• identify at least one treatment agent and at least one supplemental agent for use in the context of the at least one treatment target and the at least one defined level of incidence, including at least:
• apply the at least one defined level of incidence and the at least one characteristic of the subpopulation identifier to identify at least one particular clinically relevant study data;
• identify a list of treatment agent options based at least partly on the defined level of incidence associated with the at least one characteristic of the subpopulation identifier, the at least one level of efficacy, and the identified at least one particular study data;
• and
• identify a corresponding list of supplemental agent options known to at least one of increase the efficacy or decrease the level of incidence of the at least one treatment agent;
• transmit for display on at least one display device the list of treatment options and the corresponding list of supplemental agent options, the options ranked based at least partly on the level of efficacy and the level of incidence when the at least one treatment agent is administered in conjunction with the at least one supplemental agent and correlating the treatment agent options with corresponding supplemental agent options;
• and
• initiate administration of at least a portion of the at least one treatment agent and the at least one supplemental agent to the at least one patient.

A computer program product comprising:

• a non-transitory computer-readable medium bearing at least:
• one or more instructions for accepting at least one treatment target pertaining to at least one patient via at least one user interface;
• one or more instructions for determining, based at least partly on a least one tissue sample from the at least one patient, at least one characteristic of a subpopulation identifier, wherein the at least one characteristic includes at least one of a genetic expression parameter, an epigenetic expression parameter, or a demographic parameter;
• one or more instructions for receiving at least one input indicating at least one minimum level of efficacy for at least one treatment agent;
• one or more instructions for identifying at least one defined level of incidence of at least one adverse event via the at least one user interface, the defined level of incidence associated with the at least one characteristic of a subpopulation identifier;
• one or more instructions for identifying at least one treatment agent and at least one supplemental agent for use in the context of the at least one treatment target and the at least one defined level of incidence, including at least:
• one or more instructions for applying the at least one defined level of incidence and the at least one characteristic of the subpopulation identifier to identify at least one particular clinically relevant study data;
• one or more instructions for identifying a list of treatment agent options based at least partly on the defined level of incidence associated with the at least one characteristic of the subpopulation identifier, the at least one level of efficacy, and the identified at least one particular study data;
• and
• one or more instructions for identifying a corresponding list of supplemental agent options known to at least one of increase the efficacy or decrease the level of incidence of the at least one treatment agent;
• one or more instructions for transmitting for display on at least one display device the list of treatment options and the corresponding list of supplemental agent options, the options ranked based at least partly on the level of efficacy and the level of incidence when the at least one treatment agent is administered in conjunction with the at least one supplemental agent and correlating the treatment agent options with corresponding supplemental agent options;
• and
• one or more instructions for initiating administration of at least a portion of the at least one treatment agent and the at least one supplemental agent to the at least one patient.