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AssigneePresident and Fellows of Harvard College
InventorsSebastian Hiller, Gerhard Wagner
Estimating the term…
Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.
A nuclear magnetic resonance (NMR) system, comprising:
A method of operating a nuclear magnetic resonance (NMR) system, the method comprising:
At least one computer-readable storage medium encoded with computer-executable instructions that, when executed by at least one processor of a nuclear magnetic resonance (NMR) system, cause the NMR system to perform a method comprising acts of:
Dependencies are inferred from the claim text.