Biomarker of renal dysfunction

A method of treating a subject at increased risk of renal dysfunction induced by at least one of physical trauma, hypotension, sepsis, and septic shock syndrome, wherein the method includes the step of:

• a) obtaining a urine sample from a subject after the at least one of physical trauma, hypotension, sepsis and septic shock syndrome;
• b) detecting the anti-inflammatory cytokine present in the urine sample obtained in step a), wherein the anti-inflammatory cytokine is selected from the group consisting of IL-1ra, TNFsr1 and TNFsr2 and any combination thereof;
• c) detecting the anti-inflammatory cytokine in a post-event normal control;
• d) calculating the level of anti-inflammatory cytokine detected in step b) relative to the level of anti-inflammatory cytokine detected in step c);
• e) determining that the subject has a greater than normal chance of developing renal dysfunction induced by physical trauma, hypotension, sepsis and/or septic shock syndrome when the level of anti-inflammatory cytokine determined in step b) is lower than the level of anti-inflammatory cytokine detected in step c);
• and
• f) applying therapeutic measures to treat or obviate the predicted impending renal dysfunction to the subject wherein the therapeutic measures are selected from maintaining a supra-normal blood pressure;
• ensuring adequate tissue oxygen delivery;
• administration of steroids;
• renal replacement therapy;
• dialysis;
• or any combination thereof.