Treating patients based on immune subtypes
AssigneeMayo Foundation for Medical Education and Research
InventorsAllan B. Dietz, Michael P. Gustafson, Yi Lin
Life of this patent
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Abstract
This document provides methods and materials for treating patients following an assessment of immune subtypes such as an assessment of peripheral blood phenotypes. For example, methods and materials for treating a mammal having a medical condition after assessing a mammal's level of CD14+/DR− cells (e.g., CD14+/DR− monocytes) and level of CD4+ cells (e.g., CD4+ T cells) and classifying the mammal has being likely to experience a favorable or unfavorable medical outcome based at least in part on the mammal's level of CD14+/DR− cells and level of CD4+ cells are provided.
Claims3
A method for treating cancer, wherein said method comprises:
- (a) detecting the presence of an elevated level of CD14+/DR− cells for said cancer in a mammal having said cancer,
- (b) detecting the presence of a reduced level of CD4+ cells for said cancer in said mammal, and
- (c) administering, to said mammal, (i) a chemotherapy with or without surgery and (ii) an anti-CTLA-4 antibody, Ipilumimab, or an anti-PD1 antibody.
Dependencies are inferred from the claim text.