Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
AssigneeIntuitive Biosciences, Inc.
InventorKimberly Luke
Life of this patent
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Abstract
The present invention relates to novel peptides that may be used in whole or in combination for the detection of Mycobacterium tuberculosis infection. In particular, the present invention relates to compositions and methods involving detection of antibodies contained in the blood of non-human primates that arise from an infection from M. tuberculosis or vaccination using an epitope specific inoculation. More particularly, the present invention provides a means to distinguish early, active, and latent M. tuberculosis infection. More particularly, the present invention describes an immunological diagnostic mechanism for the detection of M. tuberculosis infection.
Claims7
A method of monitoring, detecting or diagnosing infection by Mycobacterium tuberculosis in a subject or subjects comprising:
- contacting an immunoassay device with a biological sample from said subject, wherein said immunoassay device comprises a first capture agent comprising a base peptide comprising SEQ ID NO:141 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a second capture reagent comprising a base peptide comprising SEQ ID NO:145 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a third capture reagent comprising a peptide encoding SEQ ID NO:
- 147;
- and a fourth capture reagent comprising a peptide encoding SEQ ID NO:98 and
- detecting the presence of antibodies in said biological sample that bind to said at least one capture reagent.
A method of monitoring, detecting or diagnosing infection by Mycobacterium tuberculosis in a subject or subjects comprising:
- detecting the presence of antibodies in a biological sample from said subject or subjects that bind to a first capture agent comprising a base peptide comprising SEQ ID NO:141 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a second capture reagent comprising a base peptide comprising SEQ ID NO:145 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a third capture reagent comprising a peptide encoding SEQ ID NO:
- 147;
- and a fourth capture reagent comprising a peptide encoding SEQ ID NO:98.
Dependencies are inferred from the claim text.