Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
AssigneeGenentech, Inc.
InventorsBrian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
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Abstract
The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
Claims7
A kit for determining the presence of the degenerative disease-associated polymorphism rs4698775 in the CFI gene and rs1329428 in the CFH gene in a biological sample, comprising reagents and instructions for detecting the genotype of the biological sample for the presence of the degenerative disease-associated polymorphisms rs4698775 in the CFI gene and rs1329428 in the CFH gene, wherein the reagents comprise a set of oligonucleotides having at least 90% identity to and the 3′ terminal nucleotide of SEQ ID NOs:
- 17, 19, 34, and 36, a set of oligonucleotides having at least 90% identity to SEQ ID NOs:
- 21 and 38 and a 5′ threoninol-FAM, and a set of oligonucleotides having at least 90% identity to SEO ID NOs:
- 23 and 40 and a 5′-threoninol-HEX.
Dependencies are inferred from the claim text.