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US 10,093,950 B2Granted
Yeast strains with reduced fatty alcohol oxidase activity and method for the production of Ω-hydroxy fatty acids and dicarboxylic acids
AssigneeProvivi, Inc.
InventorsMichael Gatter, Falk Matthaus, Gerold Barth
Life of this patent
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Abstract
The invention relates to various new yeast strains of the type Yarrowia lipolytica as well as relevant methods for the biocatalytic preparation of ω-hydroxy fatty acids or dicarboxylic acids with the aid of these strains, whereby the formation of ω-hydroxy fatty acids or dicarboxylic acids is advantageously increased.
Claims13
A genetically engineered Yarrowia lipolytica strain with reduced fatty alcohol oxidase activity as compared to that of a wild type Yarrowia lipolytica strain,
- wherein said genetically engineered Yarrowia lipolytica strain is engineered to eliminate the expression or activity of endogenous fatty alcohol oxidase encoded by the FAO1 YALI0B14014g gene, and
- wherein the strain is further engineered to eliminate the expression or activity of each of the following endogenous acyl-CoA oxidases:
- POX1, POX2, POX3, POX4, POX5, and POX6.
Dependencies are inferred from the claim text.