AAV-directed persistent expression of an anti-nicotine antibody gene for smoking cessation
AssigneeCornell University
InventorsRonald G. Crystal, Martin J. Hicks, Jonathan B. Rosenberg, Bishnu P. De, Stephen M. Kaminsky, Robin L. Davisson
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Abstract
The invention is directed to an adeno-associated virus (AAV) vector which comprises a nucleic acid sequence encoding an antibody or antigen binding fragment that binds to nicotine or a nicotine analog. The invention also is directed to a composition comprising the AAV vector and methods of using the AAV vector to induce an immune response against nicotine in a mammal.
Claims12
An adeno-associated virus (AAV) vector comprising a nucleic acid sequence which encodes an antibody that binds nicotine or a nicotine analog, or an antigen-binding fragment thereof, wherein the antibody comprises a heavy chain polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 and a light chain polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.