Back to results
US 10,093,929 B2Granted
Modular RNA regulators and methods
OwnerFu-Sen Lianginventor
Life of this patent
Estimating the term…
Abstract
This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator molecules include a recognition module and an inhibition module. Generally, the recognition module includes a polynucleotide in which at least a portion of the polynucleotide recognizes at least a portion of a preselected pre-miRNA. Generally, the inhibition module includes a moiety that inhibits nuclease processing of the preselected pre-RNA to a mature RNA.
Claims15
A modular RNA regulator molecule comprising:
- a recognition module comprising a chemical moiety that recognizes at least a portion of a preselected pre-RNA, but does not inhibit nuclease processing of the preselected pre-RNA;
- an inhibition module comprising a moiety that inhibits nuclease processing of the preselected pre-RNA to a mature RNA;
- and
- a linker module linking the recognition module and the inhibition module, the linking module comprising non-nucleotide small molecule moiety.
1 more element
Dependencies are inferred from the claim text.