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US 10,093,926 B2Granted
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
AssigneeRegulus Therapeutics Inc.
InventorsC. Frank Bennett, Susan M. Freier, Richard H. Griffey
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
Claims20
A method of inhibiting the activity of miR-132 (SEQ ID NO:
- 206), comprising contacting a cell comprising miR-132 with a compound comprising an oligonucleotide, wherein:
- the oligonucleotide is 100% complementary to miR-132;
- the oligonucleotide consists of 15 to 30 linked monomeric subunits;
- and
- at least one monomeric subunit comprises a modified sugar moiety.
2 more elements
Dependencies are inferred from the claim text.