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US 10,093,918 B2Granted
Sample collection and analysis devices
AssigneeLucigen Corporation
InventorsCindy Mielke, Kyle Williamson, James Koelbl, Dylann Ceriani, Chris da Costa, Espir Kahatt
Life of this patent
Estimating the term…
Abstract
Devices and methods for collecting, processing, and analyzing a sample. A sample collection module is configured for collecting, mixing diluting, and filtering a sample for analysis. A reaction cartridge is configured for processing a sample, mixing it with dried reagents, and conducting a chemical reaction for detecting target analytes.
Claims30
A reaction cartridge comprising:
- a pressurizable first chamber;
- a first pressure actuator in fluid communication with the first chamber;
- a first valve in fluid communication with the first chamber;
- a second valve in fluid communication with the first valve;
- a reversibly pressurizable second chamber in fluid communication with the first valve and the second valve;
- a second pressure actuator in fluid communication with the second chamber;
- a reversibly pressurizable third chamber in fluid communication with the second valve;
- a third pressure actuator in fluid communication with the third chamber;
- a third valve in fluid communication with the second valve and the third chamber;
- and
- a fourth chamber in fluid communication with the third valve, wherein:
- pressurizing the first chamber through the first pressure actuator with the first valve open and with the second valve closed moves liquid from the first chamber to the second chamber;
- pressurizing the second chamber through the second pressure actuator with the second valve open and with the first valve and the third valve closed moves liquid from the second chamber to the third chamber;
- pressurizing the third chamber through the third pressure actuator with the second valve open and with the first valve and the third valve closed moves liquid from the third chamber to the second chamber;
- and
- pressurizing the third chamber through the third pressure actuator with the second valve closed and the third valve open moves liquid from the third chamber to the fourth chamber.
13 more elements
A reaction cartridge comprising:
- a pressurizable first chamber;
- a first pressure actuator in fluid communication with the first chamber;
- a first valve in fluid communication with the first chamber;
- a second valve in fluid communication with the first valve;
- a reversibly pressurizable second chamber in fluid communication with the first valve and the second valve;
- a second pressure actuator in fluid communication with the second chamber;
- a reversibly pressurizable third chamber in fluid communication with the second valve;
- a third pressure actuator in fluid communication with the third chamber;
- a third valve in fluid communication with the second valve and the third chamber;
- and
- a fourth chamber in fluid communication with the third valve, wherein:
- the first valve is in fluid connection with the second valve via a channel that does not pass through the second chamber;
- the second valve is in fluid connection with the third valve via a channel that does not pass through the third chamber;
- or
- the first valve is in fluid connection with the second valve via a channel that does not pass through the second chamber and the second valve is in fluid connection with the third valve via a channel that does not pass through the third chamber.
12 more elements
A reaction cartridge comprising:
- a pressurizable first chamber;
- a first pressure actuator in fluid communication with the first chamber;
- a first valve in fluid communication with the first chamber;
- a second valve in fluid communication with the first valve;
- a reversibly pressurizable second chamber in fluid communication with the first valve and the second valve;
- a second pressure actuator in fluid communication with the second chamber;
- a reversibly pressurizable third chamber in fluid communication with the second valve;
- a third pressure actuator in fluid communication with the third chamber;
- a third valve in fluid communication with the second valve and the third chamber;
- and
- a fourth chamber in fluid communication with the third valve, wherein:
- the first valve is in fluid connection with the second valve via a channel that does not pass through the second chamber;
- the second valve is in fluid connection with the third valve via a channel that does not pass through the third chamber;
- or
- the first valve is in fluid connection with the second valve via a channel that does not pass through the second chamber and the second valve is in fluid connection
- with the third valve via a channel that does not pass through the third chamber, wherein:
- pressurizing the first chamber through the first pressure actuator with the first valve open and with the second valve closed moves liquid from the first chamber to the second chamber;
- pressurizing the second chamber through the second pressure actuator with the second valve open and with the first valve and the third valve closed moves liquid from the second chamber to the third chamber;
- pressurizing the third chamber through the third pressure actuator with the second valve open and with the first valve and the third valve closed moves liquid from the third chamber to the second chamber;
- and
- pressurizing the third chamber through the third pressure actuator with the second valve closed and the third valve open moves liquid from the third chamber to the fourth chamber.
18 more elements
Dependencies are inferred from the claim text.