Homopolymer nanoparticles by self-emulsion polymerization reaction and preparation method thereof
AssigneeGwangju Institute of Science and Technology
InventorsJae-Suk Lee, Santosh Kumar, Dong Woo Kim, Mohammad Changei, Hong-Joon Lee
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Abstract
Disclosed herein is a preparation method of homopolymer nanoparticles without using a surfactant. The homopolymer nanoparticles prepared thereby are expected to be widely used not only as a template of a semiconductor metal oxide, a drug delivery system (DDS), an electron transport layer (ETL), and a seed having vertical structural shape, but also in a high precision field such as replacement of an organic device polystyrene bead film.
Claims8
A preparation method of homopolymer nanoparticles comprising:
- (i) preparing a deoxygenated mixture of water and an amphiphilic monomer selected from the group consisting of vinylpyridine, 4-vinylpyridine, acrylic acid, methacrylic acid, styrene sulfonic acid, 4-styrene sulfonic acid, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, methacrylamide, n-vinylpyrrolidone, acrylonitrile, 4-(4-vinylphenyl)pyridine, and 6-vinylpyridine-3-carbonitrile;
- (ii) adding a hydrophilic initiator to said mixture to initiate a surfactant-free polymerization reaction of amphiphilic monomers;
- (iii) carrying out the surfactant-free polymerization reaction at constant temperature ranging from 55° C. to 95° C. for 50-160 minutes to form the homopolymer nanoparticles.
Homopolymer nanoparticles comprising a homopolymer represented by one of the following Chemical Formulae 1-7:
- wherein n is an integer of 10 to 10,000;
- and
- wherein said nanoparticles consist of 2-1,000 homopolymers;
- have a spherical shape having a diameter of 1-800 nm;
- and have a shell composed of hydrophilic pendants of said homopolymers and an inner layer composed of 70-95 vol % of hydrophobic main chains of said homopolymers and 5-30 vol % of hydrophilic pendants of said homopolymers.
A preparation method of homopolymer nanoparticles comprising:
- (i) preparing a deoxygenated mixture of water and an amphiphilic monomer selected from the group consisting of vinylpyridine, 4-vinylpyridine, acrylic acid, methacrylic acid, styrene sulfonic acid, 4-styrene sulfonic acid, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, methacrylamide, n-vinylpyrrolidone, acrylonitrile, 4-(4-vinylphenyl)pyridine, and 6-vinylpyridine-3-carbonitrile;
- (ii) adding a hydrophilic initiator to said mixture to initiate a surfactant-free polymerization reaction of amphiphilic monomers;
- (iii) carrying out a surfactant-free polymerization reaction at constant temperature ranging from 55° C. to 95° C. for 50-160 minutes to form the homopolymer nanoparticles;
- (iv) swelling the homopolymer nanoparticles and collecting a pharmaceutical active material in an inner layer of said nanoparticles.
Dependencies are inferred from the claim text.