Multispecific GITR-binding fusion proteins and methods of use thereof
AssigneeInhibrx, Inc.
InventorsJohn C. Timmer, Kyle S. Jones, Amir S. Razai, Abrahim Hussain, Katelyn M. Willis, Quinn Deveraux, Brendan P. Eckelman
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Abstract
This disclosure generally provides molecules that specifically engage glucocorticoid-induced TNFR-related protein (GITR), a member of the TNF receptor superfamily (TNFRSF). More specifically, the disclosure relates to multivalent and/or multispecific molecules that bind at least GITR.
Claims57
An isolated multispecific polypeptide that specifically binds glucocorticoid-induced TNFR-related protein (GITR) and a second antigen, wherein the multispecific polypeptide is a fusion protein comprising a plurality of Tumor Necrosis Factor receptor superfamily (TNFRSF) binding domains (TBDs), wherein at least a first TBD (TBD1) comprises a GITR-binding domain (GITR-BD) that specifically binds GITR, and wherein the multispecific polypeptide is capable of enhanced clustering of TNFRSF members and induces enhanced TNSFR-dependent signaling compared to non-cross-linked bivalent antibodies.
Dependencies are inferred from the claim text.