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US 10,093,735 B2Granted
Beta-klotho binding proteins
AssigneeNGM Biopharmaceuticals, Inc.
InventorsKalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
Life of this patent
Estimating the term…
Abstract
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
Claims15
An antibody or binding fragment thereof that binds human beta klotho, which comprises:
- (a) a heavy chain CDR1 comprising SEQ ID NO:1, a heavy chain CDR2 comprising SEQ ID NO:22, a heavy chain CDR3 comprising SEQ ID NO:3;
- and (b) a light chain CDR1 comprising SEQ ID NO:4, a light chain CDR2 comprising SEQ ID NO:5, and a light chain CDR3 comprising SEQ ID NO:6.
An antibody that binds human beta klotho, which comprises a heavy chain comprising amino acids 23-472 of SEQ ID NO:317 and a light chain comprising amino acids 23-240 of SEQ ID NO:319.
Dependencies are inferred from the claim text.