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US 10,093,734 B2Granted
Blockade of RGMb for reducing transplantation-associated immune responses
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsEverett Hurteau Meyer, Rosemarie H. Dekruyff, Panagiota Iliopoulou, Yuchiao Hsu, Magdiel Perez Cruz
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Abstract
RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
Claims9
A method for reducing graft versus host disease following transplantation to a subject, the method comprising:
- administering to said subject a therapeutically effective amount of an antagonistic antibody that specifically binds to Repulsive Guidance Molecule (RGMb), wherein the graft versus host disease is reduced.
A method for reducing graft versus host disease following transplantation of hematopoietic cells to a subject, the method comprising:
- administering to said subject a therapeutically effective amount of an antagonistic antibody that specifically binds to Repulsive Guidance Molecule (RGMb), wherein graft versus host disease is reduced.
Dependencies are inferred from the claim text.