Protein sustained-release injectable formulation
AssigneeESBATech, an Alcon Biomedical Research Unit LLC
InventorsLutz Asmus, Michael Möller, Robert Gurny, John P. A. Grimshaw
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Abstract
The present invention provides sustained-release pharmaceutical formulations for administering proteins to the eye. In particular, the invention provides formulations comprising single chain antibodies and hydrophobic polyester hexylsubstituted poly(lactic acid) (hexPLA). The invention further provides processes for the production of sustained-release pharmaceutical formulations and medical uses thereof.
Claims1
A process for the preparation of a sustained-release pharmaceutical formulation, the process comprising cryo-milling a single chain antibody and hexylsubstituted poly(lactic acid) (hexPLA), wherein the single chain antibody comprises the amino acid sequence of SEQ ID NO:
- 1, and wherein the single chain antibody is present in a final concentration in the range of 1.25% to 5.0% (w/w) and the hexPLA is present at a molecular weight in the range of 2500 g/mol to 5000 g/mol.
Dependencies are inferred from the claim text.