Nucleotide sequences, vectors and host cells
AssigneeGlaxosmithkline Biologicals SA
InventorCindy Castado
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Abstract
The present invention relates to fusion proteins comprising fragments from toxin A and/or toxin B of Clostridium difficile, wherein the polypeptide elicits antibodies that neutralize toxin A or toxin B or both.
Claims24
A polynucleotide encoding a polypeptide comprising a sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7 SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25 and SEQ ID NO:27.
A polynucleotide encoding a polypeptide comprising an immunogenic fragment of an amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7 SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25 or SEQ ID NO:27, said immunogenic fragment at least 900 amino acids in length, wherein said polypeptide elicits antibodies against both toxin A and toxin B of C. difficile.
A polynucleotide encoding a polypeptide comprising the sequence of SEQ ID NO:4.
A polynucleotide encoding a polypeptide comprising an immunogenic fragment of the sequence of SEQ ID NO:4, said immunogenic fragment at least 900 amino acids in length, wherein said polypeptide elicits antibodies against both toxin A and toxin B of C. difficile.
Dependencies are inferred from the claim text.