T1R taste receptors and genes encoding same
AssigneeSenomyx, Inc.
InventorsJon Elliot Adler, Sergey Zozulya, Xiaodong Li, Shawn O'Connell, Lena Luukkonen
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Abstract
Methods are provided for identifying human and non-human primate cells which respond to sweet tastants. These methods screen for human or non-human primate cells which express a polypeptide which binds to or responds to sweet tastants. These cells may be used in binding and functional assays to screen for compounds which modulate sweet taste.
Claims15
A method of identifying putative human or non-human primate cells which respond to sweet tastants which method comprises (i) identifying human or non-human primate cells which express a polypeptide at least 90% identical to the polypeptide of SEQ ID NO:4 and (ii) modifying said cells identified in (i) to comprise a detectable label or incorporating said identified cells into a composition which comprises a detectable label which detectable label permits the use of such identified cells in assays which screen for compounds which bind to or which modulate the activity of said polypeptide expressed by the identified cells which is at least 90% identical to the polypeptide of SEQ ID NO:4.
Dependencies are inferred from the claim text.