GM-CSF and IL-4 conjugates, compositions, and methods related thereto
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsJacques Galipeau, Jiusheng Deng
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Abstract
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.
Claims3
A method of treating cancer comprising administering a conjugate comprising the amino acid sequence of SEQ ID NO:
- 8 to a subject in need thereof, wherein the cancer is a hematological malignancy.
A method of treating melanoma comprising administering a conjugate comprising the amino acid sequence of SEQ ID NO:
- 8 to a subject in need thereof.
Dependencies are inferred from the claim text.