Compositions and methods for brown fat induction and activity using FNDC5
AssigneeDana-Farber Cancer Institute, Inc.
InventorsBruce M. Spiegelman, Pontus Bostrom
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Abstract
The invention provides compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression. Also provided are methods for preventing or treating metabolic disorders in a subject through modulation of Fndc5 activity and/or expression. Further provided are methods for identifying compounds that are capable of modulating Fndc5 activity and/or expression.
Claims20
An isolated polypeptide consisting of the amino acid sequence of residues 30-140 of SEQ ID NO:2, and further comprising a heterologous polypeptide.
An isolated polypeptide consisting of the amino acid sequence of residues 30-140 of SEQ ID NO:2, and further comprising a heterologous polypeptide, wherein said heterologous polypeptide comprises an Fc domain.
Dependencies are inferred from the claim text.