Peptide having efficacy for remedying hypopigmentation and inhibiting adipogenesis, and use of same

Abstract

A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 shows a melanogenesis increment activity and an adipogenesis inhibitory activity. The peptide, by increasing phosphorylation of MITF, which is a transcription factor for increasing a tyrosinase expression, and CREB for increasing an MITF expression, consequently increases a tyrosinase expression and ultimately increases melanin synthesis. The peptide, by reducing the amount of fat accumulated inside a cell and reducing expressions of perilipin and PPARγ, which contribute to adipogenic mechanism, ultimately inhibits adipogenesis. A composition for remedying or treating melanin hypopigmentation, a composition comprising the peptide, and a pharmaceutical composition for treating or preventing obesity, are provided.

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