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US 10,093,696 B2Granted
Nitric oxide donating carnosine compounds
AssigneeNicox Science Ireland
InventorsNicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Sergio Romeo
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Abstract
The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
Claims18
A carnosine analogue of formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof:
- wherein R is:
- —(Y)—(CH2)n—[CH(ONO2)]p—CH2—ONO2 1)
- —(Y)—(CH2)n—X—(CH2)n1—[CH(ONO2)]p—CH2—ONO2 2)
- wherein:
- Y is O, NH or a covalent single bond;
- n is an integer from 1 to 10, preferably 1 to 4;
- with the proviso that in formula 2) when Y is O or NH, then n is not 1;
- n1 is an integer from 1 to 10, preferably 1 to 4;
- p is 0 or 1;
- X is O, NH or S;
- R1 is OH, —OR2, −NH2, —NHR2, wherein R2 is (C1-C10) linear or branched alkyl.
8 more elements
Dependencies are inferred from the claim text.