Sterol derivative, preparation method therefor and use thereof

An extract, wherein the extract is:

• (1) an eluent obtained by:
• taking a Monascus-fermented rice preparation, performing ultrasonic extraction after adding a solvent, and concentrating an extract liquid under reduced pressure to obtain a refined extract;
• performing column chromatography separation for the refined extract on silica gel, performing gradient elution for the refined extract by using petroleum ether and ethyl acetate during the separation process;
• volume ratios of petroleum ether to ethyl acetate during the gradient elution process are 75:25, 50:50 to 25:75 and 0:100 in turn, and obtaining an eluent when the volume ratio of petroleum ether to ethyl acetate is 50:50 to 25:75;
• or
• (2) the fourth part of fractions obtained by:
• taking a Monascus-fermented rice preparation, performing ultrasonic extraction after adding a solvent, and concentrating an extract liquid under reduced pressure to obtain a refined extract;
• performing column chromatography separation for the refined extract on silica gel, performing gradient elution for the refined extract by using petroleum ether and ethyl acetate during the separation process;
• volume ratios of petroleum ether to ethyl acetate during the gradient elution process are 75:25, 50:50 to 25:75 and 0:100 in turn;
• an eluent obtained when the volume ratio of petroleum ether to ethyl acetate is 50:50 to 25:75;
• using a mixed solution of dichloromethane and methanol with a volume ratio of 1:1 as the mobile phase, performing sephadex LH-20 gel column chromatography for, combining identical parts through Thin Layer Chromatography (TLC) tracking and detection to obtain 6 parts of fractions, and the fourth part of fractions is obtained.

A method for anti hepatoma or lymphoma, comprising a step of administering a dosage of the sterol compound with Structural Formula (I) at 0.001 to 1000 mg/kg bodyweight/day, wherein the Structural Formula (I) is as follows:

• where R1 is —OH, ═O, H or C1-C3 alkyl;
• R2 is —OH, H or C1-C3 alkyl;
• R3 is —OH, ═O, H or C1-C3 alkyl;
• R4 is —OH, H or C1-C3 alkyl, and at least one of R1, R2, R3 and R4 is —OH.

A method for treatment/or auxiliary treatment of reducing or regulating blood lipid, or treating dyslipidemia, hyperlipidemia, hypercholesterolemia, or atherosclerosis, or improving vascular endothelial function in the treatment of hepatoma or lymphoma, or inhibiting platelet aggregation, comprising a step of administering a dosage of the sterol compound with Structural Formula (I) at 0.001 to 1000 mg/kg bodyweight/day, wherein the Structural Formula (I) is as follows:

• where R1 is —OH, ═O, H or C1-C3 alkyl;
• R2 is —OH, H or C1-C3 alkyl;
• R3 is —OH, ═O, H or C1-C3 alkyl;
• R4 is —OH, H or C1-C3 alkyl, and at least one of R1, R2, R3 and R4 is —OH.