Back to results
US 10,093,689 B1Granted
Composition containing a gold (I) complex and cancer cells
AssigneesKing Fahd University of Petroleum and Minerals, King Saud University
InventorsSaid S. Al-Jaroudi, Ali Alhoshani, Muhammad Altaf, Anvarhusein Abdulkadir Isab
Life of this patent
Estimating the term…
Abstract
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.
Claims6
A composition, comprising:
- a gold(I) complex represented by formula (I):
- a salt thereof, a solvate thereof, or a combination thereof;
- cancer cells;
- and
- at least one chemotherapeutic agent selected from the group consisting of aflibercept, asparaginase, bleomycin, busulfan, carmustine, chlorambucil, cladribine, cyclophosphamide, cytarabine, dacarbazine, daunorubicin, doxorubicin, etoposide, fludarabine, gemcitabine, hydroxyurea, idarubicin, ifosfamide, irinotecan, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitoxantrone, pentostatin, procarbazine, topotecan, vinblastine, vincristine, retinoic acid, oxaliplatin, carboplatin, 5-fluorouracil, teniposide, amasacrine, docetaxel, paclitaxel, vinorelbine, bortezomib, clofarabine, capecitabine, actinomycin D, epirubicin, vindesine, methotrexate, 6-thioguanine, tipifarnib, imatinib, erlotinib, sorafenib, sunitinib, dasatinib, nilotinib, lapatinib, gefitinib, temsirolimus, everolimus, rapamycin, bosutinib, pzopanib, axitinib, neratinib, vatalanib, pazopanib, midostaurin, enzastaurin, trastuzumab, cetuximab, panitumumab, rituximab, bevacizumab, mapatumumab, conatumumab, and lexatumumab;
- wherein R1 and R2 are alkyl groups independently selected from the group consisting of methyl, ethyl and isopropyl;
- R3, R4, and R5 are independently selected from the group consisting of an optionally substituted C1-C3 alkyl, an optionally substituted C3-C5 cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted arylolefin, an optionally substituted vinyl;
- and
- with the proviso that R1, R2, R3, R4, and R5 are not each an ethyl.
6 more elements
Dependencies are inferred from the claim text.