Amino sulfonyl-based compounds, the preparation method therefor and use thereof

An aminosulfonyl-based compound represented by formula I or a tautomer, enantiomer, racemate or pharmaceutically acceptable salt thereof,

• wherein
• Z is N—R5, O or CHR5;
• when X is O and Y is N, Z is not O or CH2;
• m is an integer of 0 to 4;
• n is a integer of 0 to 2;
• p is an integer of 1 to 2;
• R1s are each independently hydrogen, amino, halogen, trifluoromethyl, hydroxyl, nitro, nitrile, mercapto, carboxyl, aldehyde group, oxo(═O) group, thio(═S) group, C1˜C10 alkyl, C2˜C10 alkenyl, C2˜C10 alkynyl, C3˜C10 cycloalkyl, C1˜C10 alkoxyl, C1˜C10 alkylacyl, C1˜C10 alkoxyl carbonyl, C1˜C10 alkylacyloxy, —NR6R7, —CONR6R7, —OCONR6R7, C1˜C10 thioalkyl, sulfonic acid group, aminoformyl, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group containing 1˜4 heteroatoms selected from a group consisting of N, O and S, or 4-˜10-membered heteroaryl containing 1˜4 heteroatoms selected from a group consisting of N, O and S;
• wherein the amino, C1˜C10 alkoxy, C1˜C10 alkyl, C1˜C10 alkyl acyl, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyloxy, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group containing 1˜4 heteroatoms selected from a group consisting of N, O and S, or 4-˜10-membered heteroaryl containing 1˜4 heteroatoms selected from a group consisting of N, O and S may be optionally substituted by one or more substituents selected from a group consisting of halogen, trifluoromethyl, hydroxyl, nitro, amino, cyano, carboxyl, aldehyde group, C1˜C10 alkyl, C1˜C10 alkoxyl, C1˜C10 alkylacyloxy, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyl, sulfonyl, C1˜C10 alkyl sufonyl, phenyl, and benzyl;
• R2s are each independently hydrogen, amino, halogen, trifluoromethyl, hydroxyl, nitro, cyano, mercapto group, carboxyl, aldehyde group, C1˜C10 alkyl, C2˜C10 alkenyl, C2˜C10 alkynyl, C3˜C10 cycloalkyl, C1˜C10 alkoxyl, C1˜C10 alkyl acyl, C1˜C10 alkoxylcarbonyl, C1˜C10 alkyl acyloxy, —NR6R7, —CONR6R7, —OCONR6R7, C1˜C10 thioalkyl, sulfonic acid group, amino formyl, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group containing 1˜4 heteroatoms selected from a group consisting of N, O and S, or 4-˜10-membered heteroaryl containing 1˜4 heteroatoms selected from a group consisting of N, O and S;
• wherein the amino, C1˜C10 alkoxy, C1˜C10 alkyl, C1˜C10 alkyl acyl, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyloxy, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group or 4-˜10-membered heteroaryl may be optionally substituted by one or more substituents selected from a group consisting of halogen, trifluoromethyl, hydroxyl, nitro, amino, cyano, carboxyl, aldehyde group, C1˜C10 alkyl, C1˜C10 alkoxyl, C1˜C10 alkyl acyloxy, C1˜C10 alkoyxl carbonyl, C1˜C10 alkyl acyl, sulfonyl, C1˜C10 alkyl sulfonyl, phenyl, and benzyl;
• R3 and R4 are each independently hydrogen, amino, trofluoromethyl, hydroxyl, carboxyl, aldehyde group, amino, C1˜C10 alkyl, C2˜C10 alkenyl, C2˜C10 alkynyl, C3˜C10 cycloalkyl, C1˜C10 alkoxyl, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyl, C1˜C10 alkyl acyloxy, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group containing 1˜4 heteroatoms selected from a group consisting of N, O and S, or 4-˜10-membered heteroaryl containing 1˜4 heteroatoms selected from a group consisting of N, O and S;
• wherein the amino, C1˜C10 alkyl, C1˜C10 alkoxy, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyl, C1˜C10 alkyl acyloxy, sulfonyl, C6˜C10 aryl, 4-˜10-membered heterocyclic group containing 1 to 4 heteroatoms selected from a group consisting of N, O and S, or 4-˜10-membered heteroaryl containing 1 to 4 heteroatoms selected from a group consisting of N, O and S may be optionally substituted by one or more substituents selected from a group consisting of halogen, trifluoromethyl, hydroxyl, nitro, amino, cyano, carboxyl, aldehyde group, C1˜C10 alkyl, C1˜C10 alkoxyl, C1˜C10 alkyl acyloxy, C1˜C10 alkoxyl carbonyl, C1˜C10 alkyl acyl, sulfonyl, C1˜C10 alkyl sulfonyl, phenyl and benzyl;
• or R3 and R4 together with the N atom to which they are bonded form a 4- to 8-membered heterocyclic group or 4- to 8-membered heteroaryl containing 1 to 4 heteroatoms selected from a group consisting of N, S and O;
• R5 is H or C1˜C10 alkyl;
• and
• R6 and R7 are each independently H or C1˜C10 alkyl, or R6 and R7 together with the N atom to which they are bonded form a 4-˜8-membered heterocyclic group containing 1˜4 heteroatoms selected from a group consisting of N, S and O, or form 4-˜8-membered heteroaryl containing 1˜4 heteroatoms selected from a group consisting of N, S and O.