Azaspiro derivatives as TRPM8 antagonists

A compound of the following formula (I):

• wherein
• A is phenyl or 5 to 6 membered heteroaryl;
• B is phenyl, 5 to 6 membered heteroaryl, or 9 to 10 membered bicyclic heteroaryl;
• L is independently selected from the group consisting of:
• a chemical bond, oxygen, and —NR4—;
• X is independently selected from the group consisting of:
• —CH2—, oxygen, and NH;
• RA and RB are independently selected from the group consisting of:
• (1) hydrogen and (3) (C1-C6)alkyl;
• or RA and RB form an oxo group (═O);
• R1 is independently selected from the group consisting of:
• (2) halogen, (8) (C1-C6)haloalkyl, (9) (C1-C6)alkoxy, and (10) (C1-C6)haloalkoxy;
• or alternatively, when q is 2, 3 or 4, then one R1 or two R1s is or are halogen or two halogens, and the other R1 or R1s is or are independently (6) (C1-C6) alkyl;
• R2 is independently selected from the group consisting of:
• (1) hydrogen, (2) fluorine, (3) chlorine, (4) iodine, (7) hydroxyl, (10) (C1-C6)alkyl, (12) (C1-C6)alkoxy, (13) (C1-C6)haloalkyl and (14) (C1-C6)haloalkoxy;
• R3 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) cyano, (5) hydroxyl, (8) (C1-C6)alkylsulfonyl, (9) —NR5R6, (10) —C(═O)NR5R6, (12) (C1-C6)alkyl, (14) (C1-C6)alkoxy(C0-C6)alkyl, and (16) —C(═O)(C1-C6)alkyl;
• wherein the (C1-C6)alkyl and (C1-C6)alkoxy(C0-C6)alkyl are optionally substituted with 1 to 3 substituents independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) cyano, and (9) —NR6R5;
• wherein R5 and R6 together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain an atom selected from oxygen and nitrogen;
• and the 3 to 7 membered ring is optionally substituted with a substituent selected from the group consisting of:
• (1) hydrogen, (3) hydroxyl, and (7) (C1-C6)alkoxy;
• R4 is independently selected from the group consisting of:
• (1) hydrogen and (2) (C1-C6)alkyl;
• R5 and R6 are independently selected from the group consisting of:
• (1) hydrogen, (2) (C1-C6)alkyl, (5) hydroxyl(C1-C6)alkyl, (6) (C1-C6)alkoxy(C1-C6)alkyl, and (7) H2N—(C1-C6)alkyl;
• p is 1, 2 or 3;
• q is 1, 2, 3 or 4;
• r is 1 or 2, and when r is 2, then R2 is the same or different;
• s is 1 or 2, and when s is 2, then R3 is the same or different;
• or a pharmaceutically acceptable salt thereof.