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US 10,093,674 B2Granted
Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases
AssigneeBrandeis University
InventorBing Xu
Life of this patent
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Abstract
Disclosed are nucleopeptide compounds that include a nucleobase, and an amino acid. Certain compounds further comprise a glycoside. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell.
Claims12
A hydrogelator of Formula I(b)
- wherein
- is cytosinyl, guaninyl, adeninyl, or thyminyl;
- each R is independently H or alkyl;
- n is 2 or 5, whereby the peptide defined by
- in Formula I(b) is LPhe-LPhe or LPhe-LPhe-LArg-LGly-LAsp;
- and
- is glucosyl, or chondrosinyl.
4 more elements
Dependencies are inferred from the claim text.