Back to results
US 10,093,669 B2Granted
Derivatives and methods of treating hepatitis B infections
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Scott Kuduk
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
Claims10
A compound having the structure of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein
- Y is —C(O)— or —SO2—;
- R1 is selected from the group consisting of C3-C6-cycloalkyl, C4-C5-heterocyclyl, —OH, C1-C4-alkyl, halo, and C3-C4-alkenyl, wherein alkyl, cycloalkyl, heterocyclyl, and alkenyl are optionally substituted with 1, or 2 groups each independently selected from —OH, halo, and methyl;
- R2 is, at each occurrence, independently selected from H, or C1-C4-alkyl;
- R3 is from H;
- R4 is selected from C5-heteroaryl and C6-aryl, wherein heteroaryl and aryl are substituted with 1 or 2 groups, each independently selected from halo, CN, or C1-C4-alkyl;
- and
- R7 is H.
5 more elements
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- Y is selected from a bond, —C(O)—, and —SO2—;
- Z is selected from —(CR5R6)mO— and —(CR5R6)m—NR7—;
- R1 is selected from the group consisting of C3-C6-cycloalkyl, C4-C5-heterocyclyl, C1-C4-alkyl, halo, and C3-C4-alkenyl, wherein alkyl, cycloalkyl, heterocyclyl, and alkenyl are optionally substituted with 1 or 2 groups each independently selected from —OH, halo, and methyl;
- R2 is, at each occurrence, independently selected from H and C1-C4-alkyl;
- R3 is, at each occurrence, H;
- R4 is selected from C6-aryl and C5-heteroaryl, wherein aryl and heteroaryl are optionally substituted with 1 or 2 groups, each independently selected from halo, CN, and C1-C4-alkyl;
- R5 is, at each occurrence, H;
- R6 is, at each occurrence, H;
- R7 is H;
- m is 0 or 1;
- and
- n is 1.
10 more elements
Dependencies are inferred from the claim text.