Coumarinyl-thiazole-sulfonyl conjugate and preparation thereof
AssigneesCOMSATS Institute of Information Technology, Quaid-I-Azam University
InventorsAamer Saeed, Khalid Rauf, Yasser M S A Alkahraman
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Abstract
The present application relates to a compound of formula (I) The present application also relates to synthesizing the compound of formula I and treating a patient with the compound of formula I having a neuropsychiatric illnesses such as a depressive disorder, schizophrenia; alcohol, nicotine, and morphine withdrawal induced depression and hyperalgesia; neuropathic pain caused by anticancerous drugs; diabetic neuropathic pain; obsessive compulsive disorder; alcohol withdrawal syndrome; static and dynamic allodynia in diabetic and cancer patients on anticancer therapy and chronic pain therapy.
Claims6
A compound having a structure of formula (I):
- wherein:
- R1 is selected from the group consisting of H, alkyl (C1-C17), X, NO2, and CN;
- R2 is selected from the group consisting of H, alkyl (C1-C17), X, NO2, and CN;
- R3 is selected from the group consisting of:
- R5 is selected from the group consisting of NH2, NH-alkyl, NH-aryl, NH-heteroaryl, X, NO2, and CN;
- R6 is selected from the group consisting of NH2, NH-alkyl, NH-aryl, NH-heteroaryl, X, NO2, CN, —CH2Ph-substitued phenyl, and heteroaryl alkyl (C1-C17);
- and
- X is a halogen;
- or a pharmaceutically acceptable salt of the compound.
A compound having a structure of formula (Ia)
- or a pharmaceutical acceptable salt of the compound.
Dependencies are inferred from the claim text.