Deuterated O-sulfated beta lactam hydroxamic acids and deuterated N-sulfated beta lactams

A compound of Formula (II):

• or a pharmaceutically acceptable salt, hydrate, or solvate, thereof, wherein:
• each of X and Y is independently selected from —CH3 and —CD3;
• at least one of X and Y is —CD3;
• each of R15, R17, and R18 is independently selected from hydrogen and deuterio;
• and
• the level of deuterium enrichment at each position denoted D is at least 50%.