Sulfoximine substituted quinazolines for pharmaceutical compositions

A compound of formula

• wherein
• Ar is
• wherein
• X is CH or N;
• R3 is H, halogen, CN or C(═O)—NH2;
• and
• R4 is
• wherein
• is a single or a double bond;
• n is 0 or 1;
• Y is O or NRN1;
• RN1 is selected from the group consisting of H, C1-3-alkyl, —C(O)—C1-3-alkyl, —C(O)—O—(CH2)1-3-phenyl and SO2—C1-3-alkyl;
• R7 is selected from the group consisting of F, CN, OH, —O—(C1-3-alkyl), —O—(CH2)1-3—(C3-7-cycloalkyl), —O—(CH2)1-3-phenyl, —O-oxetanyl and —O—C(O)—C1-4-alkyl;
• and
• R9 is H, or R9 together with R7 form —CH2— or —(CH2)2—;
• wherein each alkyl group mentioned in the definition of RN1 and R7 is optionally substituted with one or more F or —O—(C1-3-alkyl);
• R1 is
• wherein
• R5 is selected from the group consisting of C1-5-alkyl, C2-3-alkenyl, C2-3-alkynyl, C3-7-cycloalkyl, heterocyclyl, heteroaryl, and aryl,
• wherein each alkyl group of R5 is optionally substituted with one or more F or with one —O—(C1-3-alkyl), —O—C3-7-cycloalkyl, —O-heterocyclyl, C3-7-cyclo-alkyl, heterocyclyl or phenyl;
• and
• R6 is C1-3-alkyl which is optionally substituted with one or more F,
• or wherein R5 and R6 together with the sulfur atom to which they are attached form a 3 to 7-membered saturated or partly unsaturated heterocycle that further to the sulfur atom may contain one additional heteroatom selected from the group consisting of O, S and NRN2,
• wherein RN2 is H, C1-3-alkyl, —C(═O)—(C1-3-alkyl), —C(═O)—O—(C1-4-alkyl), —C(═O)—(C1-3-alkyl)-O—(C1-4-alkyl), —C(═O)—NH2, —C(═O)—NH(C1-3-alkyl), —C(═O)—N(C1-3-alkyl)2 or —SO2(C1-4-alkyl);
• and wherein R5, R6 and the heterocycles formed by R5 and R6 together with the sulfur atom to which they are attached may each be independently substituted with halogen, CN, OH, C1-3-alkyl or —O—(C1-3-alkyl);
• and
• R2 is selected from the group consisting of halogen, CN, OH, C1-3-alkyl, C3-5-cycloalkyl and —O—(C1-3-alkyl), wherein each alkyl group is optionally substituted with one or more F;
• and
• Rx is H or halogen;
• and
• wherein, if not otherwise specified, each alkyl group in the above definitions is linear or branched and may be substituted with one to three F;
• or a stereoisomer or salt thereof.